The genetic control of renal development.
The genetic control of renal development.
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DOI：
10.1097/00041552-199505000-00010
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发表时间：
1995-05-01
影响因子：
3.2
通讯作者：
Dressler, G R
中科院分区：
文献类型：
--
作者：
Dressler, G R
哺乳动物肾脏器官发生的分子基础正在多个水平上进行研究，取得了一些令人振奋的进展。肾脏诱导过程中和之后的细胞信号可能部分由Wnt基因介导，Wnt基因编码分泌的基质相关多肽。肾间充质对诱导的反应需要Wilms的肿瘤抑制基因WT1；转录因子Pax-2可能在诱导后立即调节肾间充质的聚集和增殖。尽管信号分子、其受体和转录因子在肾脏中的激活和抑制之间的联系仍未确定，但目前已确定了驱动肾脏形态发生的遗传级联的几个关键因素。
The molecular basis of the organogenesis of the mammalian kidney is being investigated at multiple levels, with several exciting developments. Cellular signaling during and after kidney induction may be mediated in part by Wnt genes, which encode secreted, matrix-associated peptides. The Wilms' tumor suppressor gene WT1 is required for the kidney mesenchyme to respond to induction; the transcription factor Pax-2 may regulate the aggregation and proliferation of the kidney mesenchyme immediately after induction. Although the links between signaling molecules, their receptors, and the activation and repression of transcription factors in the kidney remain to be determined, several key elements of the genetic cascade driving kidney morphogenesis are now characterized.