THE MECHANISM OF ANAEROBIC, RADICAL-INDUCED DNA STRAND SCISSION
THE MECHANISM OF ANAEROBIC, RADICAL-INDUCED DNA STRAND SCISSION
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DOI：
10.1002/anie.199317421
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发表时间：
1993-12-01
影响因子：
16.6
通讯作者：
SCHAFER, T
中科院分区：
文献类型：
--
作者：
GIESE, B;BEYRICHGRAF, X;SCHAFER, T
放射性或化学产生的自由基可以通过H提取来切割DNA链。在此过程中的一个重要中间体是4 '-脱氧核糖核苷酸自由基1111（方案1）。该反应性中间体可通过直接片段化或通过与0反应导致链断裂。为了解释在厌氧条件下观察到的裂解产物，Schulte-Frohlinde等人已经DroDosed，自由基阳离子2是一种
Radicals generated either radiolytically or chemically may cleave the DNA strand by H abstraction. An important intermediate in this process is the 4'-deoxyribonucleotide radical 1111 (Scheme 1). This reactive intermediate can lead to strand breakage either by direct fragmentation or by reaction with 0,. In order to account for the cleavage products that are observed under anaerobic conditions, Schulte-Frohlinde et al. have DroDosed that the radical cation 2 is an