Diastereoselective synthesis of (±)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA
Diastereoselective synthesis of (±)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA
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DOI：
10.1039/b604002k
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Johnston, Graham A. R.
中科院分区：
文献类型：
--
作者：
Hanrahan, Jane R.;Mewett, Kenneth N.;Johnston, Graham A. R.
描述了（+/-）-（3-氨基环戊烷）烷基次膦酸的两种非对映异构体的发散合成。两种非对映异构体均由关键的（+/-）-（3-羟基环戊二烯-1-烯）烷基次膦酸酯经5步获得，所述（+/-）-（3-羟基环戊二烯-1-烯）烷基次膦酸酯通过钯催化的C-P键形成反应制备。
A divergent synthesis of both diastereoisomers of (+/-)-(3-aminocyclopentane)alkylphosphinic acid is described. Both diastereoisomers are obtained in 5 steps from the key (+/-)-(3-hydroxycyclopent-1-ene) alkylphosphinate esters which are prepared via a palladium catalysed C-P bond forming reaction.