Role of the beta2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion.
Role of the beta2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion.
复制标题
β2-整合素和免疫球蛋白超家族成员在心肌缺血再灌注中的作用。
DOI：
10.1016/s0003-4975(99)01017-6
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Lefer,AM
中科院分区：
文献类型：
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作者：
Lefer,AM
白细胞在冠状动脉缺血再灌注等炎症过程中起关键作用。它们与内皮细胞的相互作用受到严格调控。这个过程的第一步是白细胞（如中性粒细胞）沿着微血管内皮滚动。这是由细胞粘附分子的选择素家族调节的，主要是p -选择素。炎症级联反应的下一步是这些中性粒细胞与活化或功能失调的内皮细胞的牢固粘附。这一过程受白细胞上的β2整合素（如CD11/CD18）和活化内皮上的ICAM-1控制。CD11/CD18是一种β2整合素，ICAM-1是粘附糖蛋白免疫球蛋白超家族的成员。通过它们的相互作用，中性粒细胞变平并粘附在血管内皮上。许多这些粘附的中性粒细胞随后能够通过内皮转移到炎症部位（即缺血再灌注的焦点）。这种转运主要是由PECAM-1刺激的，PECAM-1是免疫球蛋白超家族的另一成员。本文将简要介绍这些过程。
Leukocytes play a key role in the inflammatory processes such as ischemia-reperfusion of the coronary vasculature. Their interaction with the endothelium is closely regulated. The first step in the process is the rolling of leukocytes (eg, neutrophils) along the microvascular endothelium. This is regulated by the selectin family of cell adhesion molecules, primarily P-selectin. The next step in the inflammatory cascade is the firm adhesion of these neutrophils to the activated or dysfunctional endothelium. This process is governed by the β2-integrins on the leukocytes (eg, CD11/CD18) and by ICAM-1 on the activated endothelium. CD11/CD18 is a β2-integrin, and ICAM-1 is a member of the immunoglobulin superfamily of adhesion glycoproteins. By their interaction, neutrophils flatten out and adhere to the vascular endothelium. Many of these adhered neutrophils are then able to transmigrate across the endothelium to the site of the inflammation (ie, the focus of the ischemia-reperfusion). This transmigration is primarily stimulated by PECAM-1, another member of the immunoglobulin superfamily. These processes are discussed in this brief review.