Nitroxidergic transmission in the nucleus tractus solitarii.
Nitroxidergic transmission in the nucleus tractus solitarii.
复制标题
孤束核中的硝基氧化能传递。
DOI：
10.1111/j.1749-6632.1997.tb48633.x
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发表时间：
1997
影响因子：
5.2
通讯作者：
Talman,WT
中科院分区：
文献类型：
--
作者：
Talman,WT
Over the past two decades many studies have led to a totally new concept of signal transduction. It is now appreciated that the radical nitric oxide (NO’), produced by constitutive nitric oxide synthase (NOS), may play an important role in endotheliumderived re1axationl2 and in inhibition of platelet aggregati~ n.~ More recently, investigations have suggested that NO may also participate as an interneuronal messenger: The idea that a soluble gas might act on target neurons after freely passing through their cell membranes was first met with considerable but now it has wide acceptance! Although understanding of signal transduction mechanisms underlying such transmission is incomplete, activation of the cytoplasmic enzyme soluble guanylate cyclase (sGC) with formation of cyclic GMP (cGMP) is known to play a role.’Some have suggested that sGC, through which NO may in part mediate its actions, may serve as a “receptor” for the molecule. 8 Classic receptor mechanisms of neurotransmission are thought to be unnecessary. Through this putative signal transduction mechanism, NO has been thought to contribute to synaptic transmission both in the central and in the peripheral nervous A major contribution to the hypothesized role of NO’in neurotransmission came with studies suggesting that activation of the N-methy1-D-aspartate (NMDA) receptor leads to release of NO’from central neuronal Likewise, activation of NMDA receptors was found to be associated with activation of sGC and formation of cGMP. I2In earlier studies we showed that activation of NMDA receptors within the nucleus tractus solitarii (NTS), the primary site of termination of cardiovascular afferent nerves, leads to prominent changes in arterial blood pressure and heart rate and that NMDA receptors are integral to the baroreceptor reflex. I3 Studies from other laboratories also suggested that nitroxidergic mechanisms play a role
