Dysregulation of ion homeostasis by antifungal agents.
Dysregulation of ion homeostasis by antifungal agents.
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DOI：
10.3389/fmicb.2012.00133
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发表时间：
2012
影响因子：
5.2
通讯作者：
Rao R
中科院分区：
文献类型：
--
作者：
Zhang Y;Muend S;Rao R
Ion-signaling and transduction networks are central to fungal development and virulence because they regulate gene expression, filamentation, host association, and invasion, pathogen stress response and survival. Dysregulation of ion homeostasis rapidly mediates cell death, forming the mechanistic basis by which a growing number of amphipathic but structurally unrelated compounds elicit antifungal activity. Included in this group is carvacrol, a terpenoid phenol that is a prominent component of oregano and other plant essential oils. Carvacrol triggers an early dose-dependent Ca2+ burst and long lasting pH changes in the model yeast Saccharomyces cerevisiae. The distinct phases of ionic transients and a robust transcriptional response that overlaps with Ca2+ stress and nutrient starvation point to specific signaling events elicited by plant terpenoid phenols, rather than a non-specific lesion of the membrane, as was previously considered. We discuss the potential use of plant essential oils and other agents that disrupt ion-signaling pathways as chemosensitizers to augment conventional antifungal therapy, and to convert fungistatic drugs with strong safety profiles into fungicides.
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影响因子：
4.9
作者：
Gamarra, Soledad;Rocha, Elousa Maria F.;Perlin, David S.
通讯作者：
Perlin, David S.
DOI：
10.1073/pnas.96.6.3298
发表时间：
1999-03-16
影响因子：
11.1
作者：
Brüggemann, L;Dietrich, P;Hedrich, R
通讯作者：
Hedrich, R
DOI：
10.1016/s0006-291x(03)01528-6
发表时间：
2003-11-28
影响因子：
3.1
作者：
Kraus, PR;Heitman, J
通讯作者：
Heitman, J
影响因子：
3.2
作者：
Muend, Sabina;Rao, Rajini
通讯作者：
Rao, Rajini
DOI：
10.1007/bf00211406
发表时间：
1995-10-01
期刊：
EUROPEAN BIOPHYSICS JOURNAL
影响因子：
--
作者：
HEDRICH, R;MORAN, O;PALME, K
通讯作者：
PALME, K