Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial
Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial
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DOI：
10.1016/s2213-8587(19)30068-3
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发表时间：
2019-05-01
影响因子：
44.5
通讯作者：
Taylor, Roy
中科院分区：
文献类型：
--
作者：
Lean, Michael E. J.;Leslie, Wilma S.;Taylor, Roy
背景：直接试验评估了在初级保健主导的体重管理计划期间2型糖尿病的缓解情况。一年后，149名干预参与者中有68名(46%)处于缓解状态，36名(24%)至少减轻了15公斤体重。这项为期两年的分析的目的是评估干预效果的持久性。方法DIRECT是一项在英国初级保健诊所进行的开放标签、整群随机、对照试验。通过计算机生成的列表随机分配实践(1：1)，以根据指南(对照)提供综合的结构化体重管理计划(干预)或最佳实践护理，并对研究地点(泰恩赛德或苏格兰)和实践列表大小(>；5700或
Background The DiRECT trial assessed remission of type 2 diabetes during a primary care-led weight-management programme. At 1 year, 68 (46%) of 149 intervention participants were in remission and 36 (24%) had achieved at least 15 kg weight loss. The aim of this 2-year analysis is to assess the durability of the intervention effect.Methods DiRECT is an open-label, cluster-randomised, controlled trial done at primary care practices in the UK. Practices were randomly assigned (1:1) via a computer-generated list to provide an integrated structured weight-management programme (intervention) or best-practice care in accordance with guidelines (control), with stratification for study site (Tyneside or Scotland) and practice list size (>5700 or