LuxS/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC 8325
LuxS/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC 8325
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DOI：
10.1016/j.ijantimicag.2012.08.016
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发表时间：
2013-01-01
影响因子：
10.8
通讯作者：
Sun, Baolin
中科院分区：
文献类型：
--
作者：
Xue, Ting;Zhao, Liping;Sun, Baolin
目前对金黄色葡萄球菌感染的治疗严重依赖于细胞壁合成抑制剂抗生素，如青霉素、苯唑西林、万古霉素和替考拉宁。抗生素耐药性的增加需要开发新的方法来对抗感染。Autoinducer-2（AI-2）广泛存在于革兰氏阴性和革兰氏阳性病原体中，被认为是种内和种间交流的通用语言。本研究证实了AI-2信号传导与S.金黄色。此外，luxS突变体表现出减少自溶和上调万古霉素耐药相关的VraRS双组分调节系统。这一发现可能为沙门氏菌的抗菌治疗提供新的线索。金黄色葡萄球菌感染。(C)2012年Elsevier B. V.和国际化疗学会。All rights reserved.
Current treatment for Staphylococcus aureus infections relies heavily upon the cell wall synthesis inhibitor antibiotics such as penicillin, oxacillin, vancomycin and teicoplanin. Increasing antibiotic resistance requires the development of new approaches to combating infection. Autoinducer-2 (AI-2) exists widely both in Gram-negative and Gram-positive pathogens and is suggested as a universal language for intraspecies and interspecies communication. This study demonstrates the association between AI-2 signalling and cell wall synthesis inhibitor antibiotic susceptibility in S. aureus. In addition, a luxS mutant exhibited decreased autolysis and upregulated vancomycin resistance-associated VraRS two-component regulatory system. This finding may provide novel clues for antimicrobial therapy in S. aureus infection. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.