TOPALi: software for automatic identification of recombinant sequences within DNA multiple alignments
TOPALi: software for automatic identification of recombinant sequences within DNA multiple alignments
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DOI：
10.1093/bioinformatics/bth155
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发表时间：
2004-07-22
期刊：
影响因子：
5.8
通讯作者：
McGuire, G
中科院分区：
文献类型：
--
作者：
Milne, I;Wright, F;McGuire, G
TOPALi是一个新的Java图形分析应用程序，它允许用户识别DNA多重比对中的重组序列（自动或通过手动调查）。TOPALi允许选择三种统计方法来预测由于过去的重组而导致的断点的位置。然后使用断点预测来识别假定的重组序列及其与其他序列的关系。除了复杂的界面外，TOPALi还可以导入许多序列格式，估计和显示系统发育树，并允许交互式分析和/或自动生成HTML报告。
TOPALi is a new Java graphical analysis application that allows the user to identify recombinant sequences within a DNA multiple alignment (either automatically or via manual investigation). TOPALi allows a choice of three statistical methods to predict the positions of breakpoints due to past recombination. The breakpoint predictions are then used to identify putative recombinant sequences and their relationships to other sequences. In addition to its sophisticated interface, TOPALi can import many sequence formats, estimate and display phylogenetic trees and allow interactive analysis and/or automatic HTML report generation.