Are there non-linear relationships between alcohol consumption and long-term health? Protocol for a systematic review of observational studies employing approaches to improve causal inference.
Are there non-linear relationships between alcohol consumption and long-term health? Protocol for a systematic review of observational studies employing approaches to improve causal inference.
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DOI：
10.1136/bmjopen-2020-043985
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发表时间：
2021-03-23
期刊：
影响因子：
2.9
通讯作者：
Mewton L
中科院分区：
文献类型：
--
作者：
Visontay R;Sunderland M;Slade T;Wilson J;Mewton L
有大量的文献发现，适度饮酒可以预防某些健康状况。然而，最近的研究强调了这些发现可能是由混淆和其他偏见造成的方法论假象。虽然现代分析和研究设计方法可以减轻混淆，从而加强观察性研究中的因果推断，但它们并不经常应用于评估酒精使用与长期健康结果之间关系的研究。本系统性综述的目的是识别采用这些分析/设计方法的观察性研究，以评估饮酒与健康结果之间的关系是否为非线性。本综述旨在评估，在每个结果的基础上，这些研究发现酒精消费和健康之间的关系的强度和形式。于2020年5月检索了电子数据库（MEDLINE、PsycINFO、Embase和SCOPUS）。研究选择将遵循系统性综述和荟萃分析的首选报告项目指南。将根据合格性标准筛选文章，这些标准旨在捕获使用观察数据评估不同酒精暴露水平与任何长期健康结果（实际或替代）之间关系的研究，并且这些研究采用了至少一种预先指定的方法来增强因果推断。将使用研究设计特定工具评估纳入文章的偏倚风险。计划对结果进行叙述性综合。由于不收集主要数据，因此不需要正式的伦理批准。研究结果将通过出版的手稿、会议和研讨会发言加以传播。CRD 42020185861。
There is a substantial literature finding that moderate alcohol consumption is protective against certain health conditions. However, more recent research has highlighted the possibility that these findings are methodological artefacts, caused by confounding and other biases. While modern analytical and study design approaches can mitigate confounding and thus enhance causal inference in observational studies, they are not routinely applied in research assessing the relationship between alcohol use and long-term health outcomes. The purpose of this systematic review is to identify observational studies that employ these analytical/design-based approaches in assessing whether relationships between alcohol consumption and health outcomes are non-linear. This review seeks to evaluate, on a per-outcome basis, what these studies find the strength and form of the relationship between alcohol consumption and health to be. Electronic databases (MEDLINE, PsycINFO, Embase and SCOPUS) were searched in May 2020. Study selection will comply with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Articles will be screened against eligibility criteria intended to capture studies using observational data to assess the relationship between varying levels of alcohol exposure and any long-term health outcome (actual or surrogate), and that have employed at least one of the prespecified approaches to enhancing causal inference. Risk of bias of included articles will be assessed using study design-specific tools. A narrative synthesis of the results is planned. Formal ethics approval is not required given there will be no primary data collection. The results of the study will be disseminated through published manuscripts, conferences and seminar presentations. CRD42020185861.
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DOI：
10.1038/s41370-020-0228-0
发表时间：
2021-03
影响因子：
4.5
作者：
Arroyave WD;Mehta SS;Guha N;Schwingl P;Taylor KW;Glenn B;Radke EG;Vilahur N;Carreón T;Nachman RM;Lunn RM
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Lunn RM
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15.8
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PRISMA Group
DOI：
10.1097/ede.0b013e3181d61eeb
发表时间：
2010-05
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
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DOI：
10.1136/bmj.d636
发表时间：
2011-02-22
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Brien SE;Ronksley PE;Turner BJ;Mukamal KJ;Ghali WA
通讯作者：
Ghali WA
影响因子：
3.4
作者：
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通讯作者：
Livingston, Michael