Age, gender, and body length effects on reference serum creatinine levels determined by an enzymatic method in Japanese children: a multicenter study
Age, gender, and body length effects on reference serum creatinine levels determined by an enzymatic method in Japanese children: a multicenter study
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DOI：
10.1007/s10157-011-0452-y
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发表时间：
2011-10-01
影响因子：
2.3
通讯作者：
Kitagawa, Teruo
中科院分区：
文献类型：
--
作者：
Uemura, Osamu;Honda, Masataka;Kitagawa, Teruo
近年来，酶法已被用于测定肌酐（Cr）而不是Jaffe法。因此，有必要确定这些酶法评价日本儿童肾功能的参考血清Cr值。方法采用酶法测定日本1151例1月龄~ 18岁儿童血清铬参考值，其中男517例，女634例。被纳入研究的儿童必须没有肾脏疾病、泌尿生殖系统疾病、传染病、炎症性疾病、脱水、肌肉疾病、异常综合征、心血管疾病、恶性疾病、高血压、肝脏或胰腺疾病或怀孕。结果参考值中位数随年龄增长逐渐增大，4岁时为0.30 mg/dl， 10岁时为0.41 mg/dl。在青春期，男性的增长速度明显快于女性。我们发现了一个能够估计2-11岁儿童血清铬参考值的线性回归方程和一个能够估计所有年龄段男女儿童血清铬参考值的五次回归方程。结论酶法测定的参考血清Cr水平与年龄、性别、体长的关系，以及体长与血清Cr水平的线性和多项式关系，将适用于亚洲和日本儿童肾功能的筛查。
Background Enzymatic methods have recently been used to measure creatinine (Cr) instead of the Jaffe method. Therefore, it is necessary to determine the reference serum Cr value for these enzymatic methods to evaluate renal function in Japanese children.Methods To determine reference values of serum Cr in Japanese children, 1151 children (517 male, 634 female) aged between 1 month and 18 years had their serum Cr values measured by an enzymatic method. To be included in the study the children had to be without kidney disease, urogenital disease, infectious disease, inflammatory disease, dehydration, muscular disease, anomaly syndrome, cardiovascular disease, malignant disease, hypertension, liver or pancreas disease, or pregnancy.Results The medians of reference values increased gradually with age, i.e., 0.30 mg/dl at 4 years old and 0.41 mg/dl at 10 years old. In adolescence, they increased significantly more rapidly in males than in females. We found a linear regression equation capable of estimating the reference value of serum Cr in children aged 2-11 years, and quintic regression equations capable of estimating the reference values of serum Cr in male and female children of all ages.Conclusion The reference serum Cr levels determined by an enzymatic method related to age, gender, and body length, and our linear and polynomial equations showing the relationship between body length and serum Cr level will be applicable for screening of renal function in Asian as well as Japanese children.