Gradual meiosis-to-mitosis transition in the early mouse embryo.
Gradual meiosis-to-mitosis transition in the early mouse embryo.
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DOI：
10.1007/978-3-642-30406-4_6
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Hiiragi, Takashi
中科院分区：
文献类型：
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作者：
Courtois, Aurelien;Hiiragi, Takashi
从减数分裂到有丝分裂的转变是保证胚胎成功发育的基本过程。在小鼠中，这种转变包括分裂机制的广泛重组、中心体的建立以及纺锤体特性和特征的变化。最近的研究结果表明，这种过渡是渐进的，并持续到囊胚后期阶段。深入了解这种转变的机制将为从头中心体的形成和纺锤体大小和特性的调节提供新的见解。本文就小鼠植入前胚胎无中心体纺锤体的形成、中心粒的建立以及减数分裂向有丝分裂的转变等方面的研究进展作一综述。
The transition from meiosis to mitosis is a fundamental process to guarantee the successful development of the embryo. In the mouse, the transition includes extensive reorganisation of the division machinery, centrosome establishment and changes in spindle proprieties and characteristic. Recent findings indicate that this transition is gradual and lasts until the late blastocyst stage. In-depth knowledge of the mechanisms underlying the transition would provide new insight into de novo centrosome formation and regulation of spindle size and proprieties. Here, we review recent advances in the understanding of acentrosomal spindle formation, centriole establishment and the meiosis-to-mitosis transition in the mouse pre-implantation embryo.