Changes in the condyle and disc in response to distraction osteogenesis of the minipig mandible.
Changes in the condyle and disc in response to distraction osteogenesis of the minipig mandible.
复制标题
小型猪下颌骨牵张成骨反应中髁突和椎间盘的变化。
DOI：
10.1053/joms.2002.35733
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
L. Kaban
中科院分区：
文献类型：
--
作者：
P. Thurmüller;M. Troulis;A. Rosenberg;L. Kaban
目的
牵引成骨（DO）是下颌延长的常用技术，但颞下颌关节的变化尚未得到充分记录。本研究的目的是评估不同速率的 DO 对下颌髁突和关节盘的影响。
材料和方法
通过颌下切口在 15 只小型猪身上放置半埋式牵引器。两只未手术的动物作为对照。该协议包括 0 天延迟和 12 毫米间隙的 1、2 或 4 毫米/天的速率。处死动物后（0、24或90天），收获同侧和对侧髁和椎间盘并进行评估，以确定1）髁突形状和大小、2）髁突表面和3）关节盘的变化。
结果
对照动物的髁关节表面光滑，没有不规则或糜烂。在接受分心的动物中，随着 DO 速率的增加，同侧髁在形态和 AP 尺寸以及表面轮廓上显示出越来越多的变化。这些变化存在于对侧髁中，但程度较轻。 DO 末期同侧和对侧关节盘内侧均出现不同程度的变薄。 90 天后，除 4 mm/d DO 组外，髁突和椎间盘的变化通过重塑而减少。
结论
这项初步研究的结果表明，单侧下颌 DO 后髁突和椎间盘发生了明显变化。这些变化在较快的分散速率（4 毫米/天）下更为严重，并且在使用 1 毫米/天的速率时在中立固定期间往往会消失。
PURPOSE
Distraction osteogenesis (DO) is a commonly used technique for mandibular lengthening, but changes in the temporomandibular joint have not been well documented. The purpose of this study was to evaluate the effect of DO, at varying rates, on the mandibular condyle and articular disc.
MATERIALS AND METHODS
Semiburied distractors were placed via submandibular incisions in 15 minipigs. Two unoperated animals served as controls. The protocol consisted of 0 day latency and rates of 1, 2, or 4 mm/d for a 12-mm gap. After the animals were killed (0, 24, or 90 days), ipsilateral and contralateral condyles and discs were harvested and evaluated to determine changes in 1) condylar form and size, 2) condylar surface, and 3) the articular disc.
RESULTS
Articular surfaces of the condyles in control animals were smooth, with no irregularities or erosions. In animals undergoing distraction, ipsilateral condyles showed increasing changes in morphology and AP dimension, and surface contour irregularities as the DO rate increased. These changes were present, but to a lesser degree, in the contralateral condyles. Articular discs of both ipsilateral and contralateral sides showed variable thinning at the medial aspect at end DO. After 90 days, changes in the condyles and discs were reduced by remodeling except in the 4 mm/d DO groups.
CONCLUSIONS
Results of this preliminary study indicate that gross changes occur in condyles and discs after unilateral mandibular DO. These changes are more severe at faster distraction rates (4 mm/d) and tend to resolve during neutral fixation when a rate of 1 mm/d is used.