Carvone and perillaldehyde interfere with the serum-induced formation of filamentous structures in Candida albicans at substantially lower concentrations than those causing significant inhibition of growth
Carvone and perillaldehyde interfere with the serum-induced formation of filamentous structures in Candida albicans at substantially lower concentrations than those causing significant inhibition of growth
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DOI：
10.1021/np010621l
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发表时间：
2002-07-01
影响因子：
5.1
通讯作者：
Logan, DA
中科院分区：
文献类型：
--
作者：
McGeady, P;Wansley, DL;Logan, DA
香芹酮和紫苏醛被证明在远低于抑制生长所需的浓度时，可以抑制白色念珠菌向丝状形态的转化，而且在生物学上更具相关性。这种形态变化与白念珠菌的致病性有关；因此，这些自然产生的单萜类化合物是开发抗白念珠菌感染的治疗药物的潜在先导化合物。
Carvone and perillaldehyde were shown to inhibit the transformation of Candida albicans to a filamentous form at concentrations far lower and more biologically relevant than the concentrations necessary to inhibit growth. This morphological transformation is associated With C. albicans pathogenicity; hence these naturally occurring monoterpenes are potential lead compounds in the development of therapeutic agents against C. albicans infection.