Haemolytic activity of copper as influenced by chelating agents, albumine and chromium.
Haemolytic activity of copper as influenced by chelating agents, albumine and chromium.
复制标题
铜的溶血活性受螯合剂、白蛋白和铬的影响。
DOI：
10.1111/j.1600-0773.1984.tb01935.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
J. Alexander
中科院分区：
文献类型：
--
作者：
J. Aaseth;V. Skaug;J. Alexander
The haemolytic activity of CuSO4 (0.3 mM) in vitro was reduced in the presence of albumine (5-20 g/l). The presence of D-penicillamine, triethylene tetramine or dimercaptosuccinic acid (0.3 mM) also reduced the copper-induced haemolysis, whereas 2,3-dimercaptopropane-1-sulphonate increased the cytolysis. N-ethylmaleimide (NEM) in appropriate concentrations (1 mM), as well as chromic chloride (0.3 mM), reduced the copper-induced haemolysis. Higher concentrations of NEM (2 mM) were ineffective. The results may provide helpful suggestions as regarding the clinical treatment of copper poisoning and Wilson's disease. The results may also be helpful for the understanding of the mechanisms of haemolysis associated with copper intoxication in vivo.
