Are there sex differences in neuropsychological functions among patients with schizophrenia?
Are there sex differences in neuropsychological functions among patients with schizophrenia?
复制标题
DOI：
10.1176/ajp.155.10.1358
复制
发表时间：
1998-10-01
影响因子：
17.7
通讯作者：
Tsuang, MT
中科院分区：
文献类型：
--
作者：
Goldstein, JM;Seidman, LJ;Tsuang, MT
目的：精神分裂症患者神经心理学表现的性别差异研究报告的结果不一致，部分原因是方法上的人为因素。这里介绍的研究是专门设计来检查神经心理学表现的性别差异。据推测，精神分裂症的妇女将表现出更少的神经心理缺陷比精神分裂症的男子，他们的表现将更类似于正常妇女比精神分裂症的男子的表现将是正常的男子。方法：从一个为严重精神病患者服务的大型城市集水区的广泛服务网络中，系统地抽样了31例DSM-III-R定义的精神分裂症门诊患者。27名正常对照组受试者在性别、年龄、父母社会经济地位、种族和利手方面进行匹配。一个广泛的神经心理测试电池管理，多变量方差分析被用来测试性别和组和性别组的相互作用的影响。结果如下：与正常男性受试者相比，男性患者的所有功能均显着受损，与女性患者相比，男性患者的注意力，言语记忆和执行功能测试。女性患者表现出显着不如女性正常对照组仅在测试的注意力。执行功能视觉记忆和运动功能结论：研究结果表明，女性精神分裂症患者可能不太容易受到特定的认知缺陷，特别是那些涉及语言处理，比男性精神分裂症。
Objective: Studies of sex differences in neuropsychological performance in schizophrenia report inconsistent results, due in part to methodological artifacts. The study presented here was specifically designed to examine sex differences in neuropsychological performance. It was hypothesized that schizophrenic women would exhibit fewer neuropsychological deficits than schizophrenic men and that their performance would be more similar to that of normal women than schizophrenic men's performance would be to that of normal men. Method: Thirty-one outpatients with DSM-III-R-defined schizophrenia were systematically sampled from an extensive service network serving a large urban catchment area for seriously mentally ill persons. Twenty-seven normal comparison subjects were matched within sex on the basis of age, parental socioeconomic status, ethnicity, and handedness. An extensive neuropsychological test battery was administered, and multivariate analysis of variance was used to test for the effects of sex and group and sex-by-group interactions. Results: Male patients were significantly impaired across all functions in comparison with normal male subjects and on tests of attention, verbal memory, and executive functions in comparison with female patients. Female patients performed significantly worse than female normal comparison subjects only on tests of attention. executive functions, visual memory, and motor functions. Conclusions: The findings suggest that women with schizophrenia may be less vulnerable to particular cognitive deficits, especially those involving verbal processing, than schizophrenic men.