A Bioactive Modified Peptide, Aeruginosamide, Isolated from the Cyanobacterium Microcystis aeruginosa.
A Bioactive Modified Peptide, Aeruginosamide, Isolated from the Cyanobacterium Microcystis aeruginosa.
复制标题
一种生物活性修饰肽，铜绿酰胺，从铜绿微囊藻中分离出来。
DOI：
10.1002/chin.199950192
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
M. Jaspars
中科院分区：
文献类型：
--
作者：
L. Lawton;L. Morris;M. Jaspars
近年来，人们对从蓝藻中分离具有生物活性的化合物越来越感兴趣。3众所周知，蓝藻铜绿微囊藻（Microcystis aeruginosa）产生有毒的环肽微囊藻毒素4，但它也产生几种线性肽，这些肽是有效的蛋白酶抑制剂。这些线性肽，aerodiosins 5和microginins，6含有蓝藻特有的不寻常的氨基酸残基。最近，已报道了胰蛋白酶-aerodosin 98 B7和凝血酶-aerodosin 298 A8复合物的X射线晶体结构。本文报道了一种从蓝藻M.铜绿。
In recent years, there has been increasing interest in isolating compounds with biological activity from cyanobacteria.3 The cyanobacterium Microcystis aeruginosa is well-known for the production of the toxic cyclic peptide microcystins,4 but it also produces several linear peptides that are potent protease inhibitors. These linear peptides, the aeruginosins5 and microginins,6 contain unusual amino acid residues unique to cyanobacteria. Recently, the X-ray crystal structures of the trypsin-aeruginosin 98B7 and thrombin-aeruginosin 298A8 complexes have been reported. In this paper, we report on the structure and biological activity of a novel peptide, aeruginosamide, isolated from a bloom of the cyanobacterium M. aeruginosa.