Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy.
Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy.
复制标题
用于癌症治疗的刺激响应聚合物纳米平台
DOI：
10.3389/fbioe.2021.707319
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发表时间：
2021
影响因子：
5.7
通讯作者：
Ju S
中科院分区：
文献类型：
--
作者：
Chang D;Ma Y;Xu X;Xie J;Ju S
聚合物纳米粒子具有良好的生物相容性、生物可降解性和结构多样性，已被广泛用作药物和生物成像剂的载体。聚合物纳米颗粒在医学中的主要应用是用于癌症治疗，具有增加的肿瘤积聚、抗癌药物精确递送到靶位点、药物性质的更高溶解度和更低的全身毒性。近年来，由于其能够响应于低pH、酶、氧化还原剂、缺氧、光、温度、磁场、超声波等刺激条件而改变其物理化学性质，刺激响应性聚合物纳米平台受到越来越多的关注。刺激物的独特属性靶组织中的响应性聚合物纳米载体可以显著提高用于癌症治疗的递送药剂的生物活性。本文综述了刺激响应性聚合物纳米粒及其在肿瘤治疗诊断中的应用，包括化学药物、核酸药物和成像分子的负载。此外，我们还讨论了设计多功能聚合物纳米载体的策略，并为这些刺激响应性聚合物纳米平台的临床应用提供了前景。
Polymeric nanoparticles have been widely used as carriers of drugs and bioimaging agents due to their excellent biocompatibility, biodegradability, and structural versatility. The principal application of polymeric nanoparticles in medicine is for cancer therapy, with increased tumor accumulation, precision delivery of anticancer drugs to target sites, higher solubility of pharmaceutical properties and lower systemic toxicity. Recently, the stimuli-responsive polymeric nanoplatforms attracted more and more attention because they can change their physicochemical properties responding to the stimuli conditions, such as low pH, enzyme, redox agents, hypoxia, light, temperature, magnetic field, ultrasound, and so on. Moreover, the unique properties of stimuli-responsive polymeric nanocarriers in target tissues may significantly improve the bioactivity of delivered agents for cancer treatment. This review introduces stimuli-responsive polymeric nanoparticles and their applications in tumor theranostics with the loading of chemical drugs, nucleic drugs and imaging molecules. In addition, we discuss the strategy for designing multifunctional polymeric nanocarriers and provide the perspective for the clinical applications of these stimuli-responsive polymeric nanoplatforms.