Studying age-related macular degeneration using animal models.
Studying age-related macular degeneration using animal models.
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DOI：
10.1097/opx.0000000000000322
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Vessey KA
中科院分区：
文献类型：
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作者：
Fletcher EL;Jobling AI;Greferath U;Mills SA;Waugh M;Ho T;de Iongh RU;Phipps JA;Vessey KA
近年来，我们对与年龄相关性黄斑变性（AMD）发展相关的遗传和环境因素的理解取得了巨大进展。对各种动物视网膜变化的检查有助于我们了解该病的发病机制。值得注意的是，携带与影响人类的遗传异常相似的遗传异常的小鼠品系为理解各种遗传风险因素如何影响视网膜完整性提供了基础。然而，到目前为止，还没有一种小鼠品系以与年龄相关的方式发展出AMD的所有特征。此外，一些背景品系中存在的突变使许多小鼠品系中视网膜表型的解释变得模糊。该观点的目的是描述如何使用动物来理解AMD每个体征的重要性以及关键的遗传风险因素。
Over the recent years, there have been tremendous advances in our understanding of the genetic and environmental factors associated with the development of age-related macular degeneration (AMD). Examination of retinal changes in various animals has aided our understanding of the pathogenesis of the disease. Notably, mouse strains, carrying genetic anomalies similar to those affecting humans, have provided a foundation for understanding how various genetic risk factors affect retinal integrity. However, to date, no single mouse strain that develops all the features of AMD in a progressive age-related manner has been identified. In addition, a mutation present in some background strains has clouded the interpretation of retinal phenotypes in many mouse strains. The aim of this perspective was to describe how animals can be used to understand the significance of each sign of AMD, as well as key genetic risk factors.