The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease.

The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease.
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棕色脂肪组织功能障碍在心血管疾病发展中的作用

DOI:
10.3389/fendo.2021.652246
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发表时间:
2021
影响因子:
5.2
通讯作者:
Ruan CC
Ruan CC
中科院分区:
医学2区
文献类型:
--
作者:
Chen HJ;Meng T;Gao PJ;Ruan CC

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棕色脂肪组织(BAT)由棕色脂肪细胞和间质血管部分组成,包括内皮细胞、淋巴细胞、成纤维细胞和干细胞,在调节心血管健康和疾病中发挥着重要作用。蝙蝠作为生热器官,可通过促进糖脂代谢来增强能量消耗,从而影响机体。此外,蝙蝠也是一种内分泌器官,能够以自分泌和/或旁分泌的方式分泌脂肪因子。BAT通过减轻心脏重塑和抑制炎症反应对心血管系统起到保护作用。在这篇综述中,我们总结了从BAT发现到现在的进展,并对BAT功能障碍在心血管疾病中的作用进行了概述。
Brown adipose tissue (BAT), consisted of brown adipocytes and stromal vascular fraction, which includes endothelial cells, lymphocytes, fibroblasts and stem cells, plays a vital role in regulating cardiovascular health and diseases. As a thermogenic organ, BAT can influence body through strengthening energy expenditure by promoting glucose and lipid metabolism. In addition, BAT is also an endocrine organ which is able to secret adipokines in an autocrine and/or paracrine fashion. BAT plays a protective role in cardiovascular system through attenuating cardiac remodeling and suppressing inflammatory response. In this review, we summarize the advances from the discovery of BAT to the present and provide an overview on the role of BAT dysfunction in cardiovascular diseases.
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