The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis
The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis
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DOI：
10.1111/j.1365-2133.2005.06697.x
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发表时间：
2005-10-01
影响因子：
10.3
通讯作者：
Fluhr, JW
中科院分区：
文献类型：
--
作者：
Angelova-Fischer, I;Bauer, A;Fluhr, JW
特应性皮炎客观严重程度评估（OSAAD）评分是最近开发的一种评估特应性皮炎严重程度的量表，该量表采用无创生物工程方法和计算机辅助估计疾病程度，通过评估表皮屏障功能和特性来构建。该方法已被验证用于婴儿和儿童特应性皮炎，并与参考评分系统进行比较。本研究的目的是检验OSAAD评分作为评估成人特应性皮炎严重程度的客观工具的效度、信度和敏感性。方法选取32例成人特应性皮炎患者作为研究对象。为了评估OSAAD评分的有效性，我们将其与欧洲特应性皮炎特别工作组的特应性皮炎严重程度评分（SCORAD）指数作为参考临床严重程度量表进行了测试，并将血清白细胞介素(IL)-16水平作为监测特应性皮炎活动的实验室变量进行了测试。通过一项比较治疗前后OSAAD、SCORAD和血清IL-16水平的纵向研究来评估对变化的反应性。为了检验OSAAD评分的可靠性，我们研究了由三位独立的皮肤科医生记录的16例患者的评分的观察者间变异性，并将其与SCORAD进行比较。结果我们报告了OSAAD和SCORAD指数作为公认的参考严重程度量表之间的显著相关性。OSAAD评分与血清IL-16水平在特应性皮炎急性期显著相关。在一项纵向研究中，OSAAD评分显著下降，与皮肤检查结果的改善、SCORAD评分和IL-16血清水平的显著下降平行。我们报告了与SCORAD相比，OSAAD评分改善了观察者间的可变性。结论：这是第一个验证OSAAD评分作为评估成人特应性皮炎严重程度的敏感可靠工具的研究。
Background The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score is a recently developed scale for evaluation of severity of atopic dermatitis, constructed from the assessment of epidermal barrier function, and properties using noninvasive bioengineering methods and computer-assisted estimates of disease extent. The method has been validated for use in infants and children with atopic dermatitis and compared with a referent scoring system.Objectives The aim of the present study was to test the validity, reliability and sensitivity of the OSAAD score as an objective tool for the assessment of the severity of atopic dermatitis in adult patients.Methods Thirty-two adult patients with atopic dermatitis were included in the study. To assess the validity of the OSAAD score we tested it against the Severity Scoring of Atopic Dermatitis (SCORAD) index of the European Task Force on Atopic Dermatitis as a referent clinical severity scale, and the serum levels of interleukin (IL)-16 as a laboratory variable for monitoring the activity of atopic dermatitis. Responsiveness to change was assessed in a longitudinal study comparing OSAAD, SCORAD and serum levels of IL-16 before and after treatment. To test the reliability of the OSAAD score we studied the interobserver variability of the score recorded by three independent board-certified dermatologists in 16 patients and compared it with SCORAD.Results We report a significant correlation between the OSAAD and the SCORAD index as an acknowledged referent severity scale. The OSAAD score correlated significantly with the serum levels of IL-16 in the acute stage of atopic dermatitis. In a longitudinal study, the OSAAD score decreased significantly, parallel with improvement of the skin findings and a significant decrease in the SCORAD score and IL-16 serum levels. We report improved interobserver variability for the OSAAD score compared with SCORAD.Conclusions: This is the first study validating the OSAAD score as a sensitive and reliable tool for the assessment of the severity of atopic dermatitis in adult patients.