Evaluating the effectiveness of antidepressant therapy adjuvant to gabapentin and pregabalin for treatment of SCI-related neuropathic pain.
Evaluating the effectiveness of antidepressant therapy adjuvant to gabapentin and pregabalin for treatment of SCI-related neuropathic pain.
复制标题
评估抗抑郁治疗辅助加巴喷丁和普瑞巴林治疗 SCI 相关神经性疼痛的有效性。
DOI：
10.1080/10790268.2017.1415246
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Zhang,Jie
中科院分区：
文献类型：
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作者：
McKinley,EmilyCarol;Richardson,ElizabethJ;McGwin,Gerald;Zhang,Jie
设计：前瞻性队列研究背景：阿拉巴马大学伯明翰康复中心2012至2015年间的住院项目。参与者：突发脊髓损伤病例，年龄19-65岁。结果：Bryce-Ragnarsson疼痛分类方案和数字评定量表。结果：29名符合条件的患者完成了6个月的随访；他们的平均年龄为36.4岁，89%为男性，65%为白人。基线特征不同于开始治疗的患者(联合治疗与单一治疗)。在6个月的随访中，基线开始的治疗与过去一周(p=0.3145)或过去24小时(p=0.4107)的疼痛程度无关。然而，继续接受相同治疗的患者在醒来后30分钟的疼痛水平较低(p=0.0235)。结论：与单独治疗相比，脊髓损伤后不久开始联合应用抗惊厥和抗抑郁药物与改善6个月的疼痛控制无关。依从性患者报告的疼痛程度较低；需要进一步的分析来阐明这种联系。
Objective:To investigate if a combination of anticonvulsant and antidepressant, two primary therapies for neuropathic pain, is associated with improved pain control compared to individual therapy.Design:Prospective cohort studySetting:The University of Alabama at Birmingham Rehabilitation Center In-patient Program between 2012 and 2015.Participants:Incident SCI cases, 19–65 years of age.Outcomes:Bryce-Ragnarsson pain classification scheme and the Numerical Rating ScaleResults:Twenty-nine eligible patients completed 6-month follow-up; their average age was 36.4 years, 89% were male, and 65% were white. Baseline characteristics were not different by therapy initiated (combination versus single). At 6 months follow-up, therapy initiated at baseline was not associated with level of pain in the past week (p=0.3145) or past 24 hours (p=0.4107). However, patients who remained on the same therapy reported lower levels of pain 30 minutes after waking (p=0.0235).Conclusions:The initiation of a combination of anticonvulsant and antidepressant shortly after SCI was not associated with improved pain control at 6 months compared to individual therapy. Adherent patients reported lower levels of pain; further analysis is warranted to elucidate this association.