AN O-18(2) TARGET FOR THE PRODUCTION OF [F-18]F-2
AN O-18(2) TARGET FOR THE PRODUCTION OF [F-18]F-2
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DOI：
10.1016/0020-708x(84)90194-7
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
RUTH, TJ
中科院分区：
文献类型：
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作者：
NICKLES, RJ;DAUBE, ME;RUTH, TJ
[18 F]F2的两步生产开发了利用18 O（p，n）18 F反应的有利产率。钝化的[Ni]靶首先装入95.2%富集的18 O2，并用10-MeV质子辐照，得到150 mCi/μ A的厚靶饱和产率。18F放射性被吸附在靶壁上，允许定量地、低温地回收富集的靶气体。然后用惰性气体+ F2混合物重新填充靶，并再次照射，诱导吸附的18F和分子F2之间的同位素交换反应。在短暂轰击后，该吹扫气体适合于[18 F]F2-加成反应，特别是18 F-标记的2-脱氧-2-氟-D-葡萄糖（[18 F]-2-FDG）的合成。初步研究，其中惰性气体，F2浓度和目标温度是不同的，进行了讨论。
A 2-step production of [18F]F2 was developed that exploits the advantageous yield of the 18O(p,n)18F reaction. A passivated [Ni] target is 1st charged with 95.2% enriched 18O2 and irradiated with 10-MeV protons resulting in a thick-target saturation yield of 150 mCi/.mu.A. The 18F activity is adsorbed on the target walls, permitting quantitative, cryogenic retrieval of the enriched target gas. The target is then refilled with a noble-gas + F2 mixture and again irradiated, inducing isotopic exchange reactions between the adsorbed 18F and the molecular F2. After a brief bombardment, this purge gas is suitable for [18F]F2-addition reactions, in particular the synthesis of 18F-labeled 2-deoxy-2-fluoro-D-glucose ([18F]-2-FDG). Preliminary studies, in which the noble gas, F2 concentrations and target temperatures were varied, are discussed.