High-Performance Hybrid Bismuth-Carbon Nanotube Based Contrast Agent for X-ray CT Imaging
High-Performance Hybrid Bismuth-Carbon Nanotube Based Contrast Agent for X-ray CT Imaging
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DOI：
10.1021/acsami.6b12768
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发表时间：
2017-02-22
影响因子：
9.5
通讯作者：
Wilson, Lon J.
中科院分区：
文献类型：
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作者：
Hernandez-Rivera, Mayra;Kumar, Ish;Wilson, Lon J.
碳纳米管 (CNT) 已被用于多种生物医学应用，包括用作药物、显像剂、蛋白质、DNA 和其他材料的输送载体。在这里，我们描述了一种用于 X 射线计算机断层扫描 (CT) 成像的新型基于 CNT 的造影剂 (CA) 的合成和表征。 CA 是一种混合材料，源自超短单壁碳纳米管（20-80 nm 长，US 管）和 Bi(III) 氧代水杨酸簇，每个簇有四个 Bi(III) 离子 (Bi4C)。选择铋元素而不是碘，碘是当今临床 CT CA 中使用的常规元素，因为它具有高 X 射线衰减能力和低毒性，这使得铋成为新 CT CA 设计中更有前景的元素。新的CA含有20%重量的铋，在37摄氏度下经各种生物介质刺激48小时后没有检测到铋的释放，这证明了混合材料的两种成分之间存在强烈的相互作用。新型 Bi4C@US 管固体材料作为 CT CA 的性能已使用临床扫描仪进行了评估，发现其 X 射线衰减能力 > 2000 Hounsfield 单位 (HU)。
Carbon nanotubes (CNTs) have been used for a plethora of biomedical applications, including their use as delivery vehicles for drugs, imaging agents, proteins, DNA, and other materials. Here, we describe the synthesis and characterization of a new CNT-based contrast agent (CA) for X-ray computed tomography (CT) imaging. The CA is a hybrid material derived from ultrashort single-walled carbon nanotubes (20-80 nm long, US-tubes) and Bi(III) oxo-salicylate clusters with four Bi(III) ions per cluster (Bi4C). The element bismuth was chosen over iodine, which is the conventional element used for CT CAs in the clinic today due to its high X-ray attenuation capability and its low toxicity, which makes bismuth a more-promising element for new CT CA design. The new CA contains 20% by weight bismuth with no detectable release of bismuth after a 48 h challenge by various biological media at 37 degrees C, demonstrating the presence of a strong interaction between the two components of the hybrid material. The performance of the new Bi4C@US-tubes solid material as a CT CA has been assessed using a clinical scanner and found to possess an X-ray attenuation ability of >2000 Hounsfield units (HU).