Population Histories of the United States Revealed through Fine-Scale Migration and Haplotype Analysis
Population Histories of the United States Revealed through Fine-Scale Migration and Haplotype Analysis
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DOI：
10.1016/j.ajhg.2020.02.002
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发表时间：
2020-03-05
影响因子：
9.8
通讯作者：
Martin, Alicia R.
中科院分区：
文献类型：
--
作者：
Dai, Chengzhen L.;Vazifeh, Mohammad M.;Martin, Alicia R.
美国的人口是由几个世纪的移民、隔离、增长和全球祖先之间的混合形成的。在这里，我们利用来自国家地理地理项目的遗传、祖先出生来源和地理数据，通过研究美国32,000多人的祖先和人口结构，收集了近期人口历史的综合视图。我们确定了反映历史人口事件的移民路线和障碍。我们还通过单倍型聚类、祖先出生起源分析和本地祖先推断的结合，揭示了亚种群中亲缘关系的空间格局。这些模式的例子包括西班牙裔/拉丁裔的大量亚结构和异质性，非洲裔美国人的距离隔离，亚洲移民的亲缘性和纯合性水平升高，以及欧洲后裔的精细结构。综上所述，我们的研究结果为不同美国人口的遗传结构和人口历史提供了详细的见解。
The population of the United States is shaped by centuries of migration, isolation, growth, and admixture between ancestors of global origins. Here, we assemble a comprehensive view of recent population history by studying the ancestry and population structure of more than 32,000 individuals in the US using genetic, ancestral birth origin, and geographic data from the National Geographic Genographic Project. We identify migration routes and barriers that reflect historical demographic events. We also uncover the spatial patterns of relatedness in subpopulations through the combination of haplotype clustering, ancestral birth origin analysis, and local ancestry inference. Examples of these patterns include substantial substructure and heterogeneity in Hispanics/Latinos, isolationby-distance in African Americans, elevated levels of relatedness and homozygosity in Asian immigrants, and fine-scale structure in European descents. Taken together, our results provide detailed insights into the genetic structure and demographic history of the diverse US population.