Effect of a facemask leak on aerosol delivery from a pMDI-spacer system
Effect of a facemask leak on aerosol delivery from a pMDI-spacer system
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DOI：
10.1089/089426804322994406
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发表时间：
2004-03-01
期刊：
影响因子：
--
通讯作者：
Tiddens, HAWM
中科院分区：
文献类型：
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作者：
Esposito-Festen, JE;Ates, B;Tiddens, HAWM
这项研究的目的是研究面罩泄漏的大小和位置与间隔输出和肺剂量的关系。上呼吸道模型(SAINT模型，Erasmus MC)连接到呼吸模拟器。检查了泄漏范围在0到1.5厘米(2)之间的口罩。泄漏点位于鼻子附近或下巴附近。在模拟呼吸过程中，200亩布地奈德(普米克(R)，阿斯利康)通过带面罩的NebuChamber(R)(阿斯利康)给模型。通过在隔离器和面罩之间或在模型和呼吸模拟器之间放置过滤器来测量隔离器输出和肺剂量。滤膜上布地奈德的含量用高效液相色谱法进行定量，并表示为标称剂量的百分比。对于0、0.05、0.1、0.16、0.2、0.3和大于0.4 cm的渗漏，鼻位和下巴位置的平均间隔输出剂量分别为50、38、28、12、10、6和0%，而下巴位置的平均间隔输出剂量分别为50、40、31、11、9、4和0%。鼻位的平均肺剂量为10、8、6、3、3、1、0、0、0、0和0%，下巴位置的平均肺剂量为10、9、8、66、5、1、1、0和0%，渗漏为0、0.05、0.1、0.16、0.2、0.3、0.4、0.5、1和1.5cm2。间隔器的输出不取决于泄漏的位置。下巴附近渗漏的肺部剂量高于鼻子附近渗漏的肺部剂量。
The objective of this investigation was to study the relation between size and position of a mask leak on spacer output and lung dose. An upper-airway model (SAINT model, Erasmus MC) was connected to a breathing simulator. Facemasks with leaks ranging between 0 and 1.5 cm(2) were examined. Leaks were located close to the nose or close to the chin. During simulated breathing, 200 mu g budesonide (Pulmicort (R), AstraZeneca) was delivered to the model via NebuChamber (R) (AstraZeneca) with facemask. Spacer output and lung dose were measured by placing a filter between spacer and facemask or between model and breathing simulator, respectively. Budesonide trapped on the filter was quantified by means of HPLC, and expressed as percentage of the nominal dose. Mean spacer output doses for the nose position were 50, 38, 28, 12, 10, 6, and 0%, and for the chin position were 50, 40, 31, 11, 9, 4, and 0% for leaks of 0, 0.05, 0.1, 0.16, 0.2, 0.3, and larger than 0.4 cm, respectively. Mean lung doses for the nose position were 10, 8, 6, 3, 3, 1, 0, 0, 0, and 0%, and for the chin position were 10, 9, 8, 6 6, 5, 1, 1, 0, and 0% for leaks of 0, 0.05, 0.1, 0.16, 0.2, 0.3, 0.4, 0.5, 1, and 1.5 cm 2. Efficiency of a pMDI-spacer facemask strongly depends on the size of a facemask leak. Spacer output did not depend on the position of the leak. Lung dose was higher for leaks near the chin than for leaks near the nose.