Copper-responsive liposomes for triggered cargo release employing a picolinamide−lipid conjugate
Copper-responsive liposomes for triggered cargo release employing a picolinamide−lipid conjugate
复制标题
使用吡啶酰胺-脂质缀合物触发货物释放的铜响应脂质体
DOI：
10.1039/d2ob01977a
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发表时间：
2023
影响因子：
3.2
通讯作者：
Best, Michael D.
中科院分区：
文献类型：
--
作者：
Sagar, Ruhani;Jaremba, Emily A.;Lou, Jinchao;Best, Michael D.
在这项工作中，我们报告触发内容释放所带来的铜螯合脂质体的合成脂质开关含有吡啶酰胺头基。基于荧光素的染料渗漏测定展示了在铜处理后羧基荧光素染料货物的释放和基于铜丰度的脂质体释放的控制。我们的结果还表明，该平台对铜具有选择性，并且在用该离子处理后伴随着脂质体性质的显著变化。
In this work, we report triggered content release from liposomes brought about by copper chelation to a synthetic lipid switch containing a picolinamide headgroup. Fluorescence-based dye-leakage assays showcase release of carboxyfluorescein dye cargo upon copper treatment and control of liposomal release based on copper abundance. Our results additionally show that this platform is selective for copper and is accompanied by significant changes to liposome properties upon treatment with this ion.