SCOPe: Manual Curation and Artifact Removal in the Structural Classification of Proteins - extended Database.
SCOPe: Manual Curation and Artifact Removal in the Structural Classification of Proteins - extended Database.
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范围：蛋白质结构分类中的手动策展和伪影 - 扩展数据库。
DOI：
10.1016/j.jmb.2016.11.023
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发表时间：
2017-02-03
影响因子：
5.6
通讯作者：
Brenner SE
中科院分区：
文献类型：
--
作者：
Chandonia JM;Fox NK;Brenner SE
SCOPe（Structural Classification of Proteins - extended，http://scop.berkeley.edu）是一个扩展了蛋白质结构分类（SCOP）数据库的蛋白质结构之间关系的数据库。SCOP是根据结构和进化关系对已知结构的大多数蛋白质的结构域进行专家策划的排序。自2009年SCOP开发结束以来，SCOPe使用人工管理和高度精确的自动化工具相结合，对大多数蛋白质结构进行分类，旨在与完全手工管理的SCOP版本具有相同的准确性。SCOPe还整合和更新了ASTRAL纲要，该纲要提供了几个数据库和工具，以帮助分析SCOPe中分类的蛋白质的序列和结构。SCOPe继续对新的超家族进行高质量的人工分类，这是SCOP的一个关键特征。像表达式标签这样的工件现在被分离到它们自己的类中，以便将它们与SCOPe层次结构的其余部分中基于同源性的注释区分开来。SCOPe 2.06包含77，439个PDB条目，是SCOP中分类的38，221个结构的两倍。
SCOPe (Structural Classification of Proteins – extended, http://scop.berkeley.edu) is a database of relationships between protein structures that extends the Structural Classification of Proteins (SCOP) database. SCOP is an expert-curated ordering of domains from the majority of proteins of known structure in a hierarchy according to structural and evolutionary relationships. SCOPe classifies the majority of protein structures released since SCOP development concluded in 2009, using a combination of manual curation and highly precise automated tools, aiming to have the same accuracy as fully hand-curated SCOP releases. SCOPe also incorporates and updates the ASTRAL compendium, which provides several databases and tools to aid in the analysis of the sequences and structures of proteins classified in SCOPe. SCOPe continues high quality manual classification of new superfamilies, a key feature of SCOP. Artifacts such as expression tags are now separated into their own class, in order to distinguish them from the homology-based annotations in the remainder of the SCOPe hierarchy. SCOPe 2.06 contains 77,439 PDB entries, double the 38,221 structures classified in SCOP.