Gamma-band synchronization in the macaque hippocampus and memory formation.
Gamma-band synchronization in the macaque hippocampus and memory formation.
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DOI：
10.1523/jneurosci.0640-09.2009
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发表时间：
2009-10-07
期刊：
影响因子：
--
通讯作者：
Buffalo EA
中科院分区：
文献类型：
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作者：
Jutras MJ;Fries P;Buffalo EA
越来越多的证据表明，神经元的同步在伽马波段（30-100赫兹）可能在介导认知过程中发挥重要作用。伽马波段同步提供了两个信号之间的最佳时间关系，以产生长期突触变化，理论上这种变化是记忆形成的基础。虽然海马体中的神经元群体在伽马范围内振荡，但这些振荡在记忆形成中的作用仍然不清楚。为了解决这个问题，我们记录了猕猴进行视觉识别记忆任务时海马体中的神经元活动。在这个任务的编码阶段，海马神经元表现出γ-波段同步。此外，在编码过程中增强的伽马波段同步预测更大的后续识别记忆性能。这些同步的变化反映了海马神经元之间协调性的增强，并可能促进成功的记忆编码所必需的突触变化。
Increasing evidence suggests that neuronal synchronization in the gamma band (30–100 Hz) may play an important role in mediating cognitive processes. Gamma-band synchronization provides for the optimal temporal relationship between two signals to produce the long-term synaptic changes that have been theorized to underlie memory formation. While neuronal populations in the hippocampus oscillate in the gamma range, the role of these oscillations in memory formation is still unclear. In order to address this issue, we recorded neuronal activity in the hippocampus while macaque monkeys performed a visual recognition memory task. During the encoding phase of this task, hippocampal neurons displayed gamma-band synchronization. Additionally, enhanced gamma-band synchronization during encoding predicted greater subsequent recognition memory performance. These changes in synchronization reflect enhanced coordination among hippocampal neurons and may facilitate synaptic changes necessary for successful memory encoding.