Covariance structure of neuroticism and agreeableness: A twin and molecular genetic analysis of the role of the serotonin transporter gene
Covariance structure of neuroticism and agreeableness: A twin and molecular genetic analysis of the role of the serotonin transporter gene
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DOI：
10.1037//0022-3514.81.2.295
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发表时间：
2001-08-01
影响因子：
7.6
通讯作者：
Hamer, DH
中科院分区：
文献类型：
--
作者：
Jang, KL;Hu, S;Hamer, DH
修订后的新人格清单神经质和宜人性领域被认为是不同的因素，尽管它们之间有几个相互关联。域名。来自加拿大、德国和日本的913对同卵双胞胎和562对同卵双胞胎志愿者的数据估计了遗传相关性，这是一个由遗传影响引起的相互关联程度的指数。对来自美国的388对非双胞胎兄弟姐妹进行了5-羟色胺转运体基因5-HTTLPR的检测，以确定5-羟色胺转运体基因座在神经质和宜人性量表之间的协变中的作用。在所有四个样本中，遗传影响导致神经质和宜人性的协方差，5-羟色胺转运体基因占这些领域之间关系的10%。
The Revised,NEO Personality Inventory domains of Neuroticism and Agreeableness are considered factorially distinct despite several intercorrelations between these. domains. The genetic correlation, an index of the degree to which these intercorrelations are caused by genetic influences, was estimated using data from 913 monozygotic and 562 dizygotic volunteer twin pairs from Canada, Germany, and Japan. The serotonin transporter gene, 5-HTTLPR, was assayed in a sample of 388 nontwin sibling pairs from the United States to determine the contribution of the serotonin transporter locus to the covariation between the Neuroticism and Agreeableness scales. In all four samples, genetic influences contributed to the covariance of Neuroticism and Agreeableness, with the serotonin transporter gene accounting for 10% of the relationship between these domains.