NICOTINE VS PLACEBO GUM IN GENERAL MEDICAL-PRACTICE
NICOTINE VS PLACEBO GUM IN GENERAL MEDICAL-PRACTICE
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DOI：
10.1001/jama.261.9.1300
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发表时间：
1989-03-03
影响因子：
120.7
通讯作者：
HEALEY, ML
中科院分区：
文献类型：
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作者：
HUGHES, JR;GUST, SW;HEALEY, ML
315名参加家庭诊所并希望戒烟的吸烟者以随机、双盲的方式被分配接受尼古丁（2 mg）或安慰剂口香糖。吸烟者最初接受医生和护士的简短建议，幻灯片演示和书面材料（29至35分钟），以及戒烟后一周的单次随访（12至20分钟）。在对婚姻状况和收入进行校正后，10%的尼古丁口香糖组和7%的安慰剂口香糖组报告连续戒烟11个月，并通过了观察员和生化验证（这一差异没有统计学意义）。我们的结论是，当在非选定的吸烟者群体中使用时，沿着一般医疗实践中的短暂干预，尼古丁口香糖增加戒烟的药理学作用很小或不存在。
Three hundred fifteen smokers who attended a family practice clinic and wished to quit smoking were assigned in a random, double-blind manner to receive either nicotine (2 mg) or placebo gum. Smokers initially received brief advice from a physician and nurse, a slide presentation and written materials (29 to 35 minutes), and a single follow-up visit (12 to 20 minutes) one week after cessation. After corrections for marital status and income, 10% of those who received nicotine gum and 7% of those who received placebo gum reported continuous abstinence for 11 months and passed observer and biochemical verification (this difference was not statistically significant). We conclude that, when used in a nonselected group of smokers along with a brief intervention in a general medical practice, the pharmacologic effects of nicotine gum to increase cessation are either small or nonexistent.