Neurobehavioral syndromes in cocaine-exposed newborn infants.
Neurobehavioral syndromes in cocaine-exposed newborn infants.
复制标题
接触可卡因的新生儿的神经行为综合征。
DOI：
10.1111/j.1467-8624.1991.tb01563.x
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发表时间：
1991
影响因子：
4.6
通讯作者：
Golub,HL
中科院分区：
文献类型：
--
作者：
Lester,BM;Corwin,MJ;Sepkoski,C;Seifer,R;Peucker,M;McLaughlin,S;Golub,HL
在80名可卡因暴露婴儿和80名对照婴儿中研究了胎儿可卡因暴露对新生儿哭声特征的影响。这些组在产妇人口统计学特征和产妇在怀孕期间使用其他非法物质和酒精方面相似。这一假设是兴奋性哭泣特征与可卡因的直接影响有关，而抑郁性哭泣特征与可卡因继发于低出生体重的间接影响有关。结构方程模型（EQS）表明，可卡因对哭声的直接影响具有更长的持续时间，更高的基频，以及更高和更可变的第一共振峰频率。可卡因继发于低出生体重的间接影响导致了潜伏期更长、话语更少、振幅更低和发音困难的哭声。与未暴露的对照组相比，暴露于可卡因的婴儿出生体重较低，身长较短，头围较小。结果与可卡因暴露婴儿中可描述的2种神经行为综合征（兴奋和抑郁）的概念一致，并且这2种综合征分别是由于直接神经毒性作用和继发于宫内生长迟缓的间接作用。
The effects of fetal cocaine exposure on newborn cry characteristics were studied in 80 cocaine‐exposed and 80 control infants. The groups were stratified to be similar on maternal demographic characteristics and maternal use of other illegal substances and alcohol during pregnancy. The hypothesis was that excitable cry characteristics were related to the direct effects of cocaine, while depressed cry characteristics were related to the indirect effects of cocaine secondary to low birthweight. Structural equation modeling (EQS) showed direct effects of cocaine on cries with a longer duration, higher fundamental frequency, and a higher and more variable first formant frequency. Indirect effects of cocaine secondary to low birthweight resulted in cries with a longer latency, fewer utterances, lower amplitude, and more dysphonation. Cocaine‐exposed infants had a lower birthweight, shorter length, and smaller head circumference than the unexposed controls. Findings were consistent with the notion that 2 neurobehavioral syndromes, excitable and depressed, can be described in cocaine‐exposed infants, and that these 2 syndromes are due, respectively, to direct neurotoxic effects and indirect effects secondary to intrauterine growth retardation.