What is the nature of poststroke language recovery and reorganization?
What is the nature of poststroke language recovery and reorganization?
复制标题
DOI：
10.5402/2012/786872
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kiran S
中科院分区：
文献类型：
--
作者：
Kiran S
这篇综述主要集中在三个主题相关的性质中风后语言恢复和重组。第一个主题涉及脑卒中后失语症梗死半球的解剖和生理基质的性质，包括脑卒中后失语症患者的血流动力学反应的性质，梗死周围组织的性质，以及梗死半球的神经元可塑性潜力。本文的第二部分回顾了目前的神经影像学证据的语言恢复在急性，亚急性和慢性阶段的恢复。第三部分也是最后一部分研究了中风后失语症恢复时连接性的变化，特别是中风后白色物质连接性的变化、功能有效连接性的变化和静息状态连接性的变化。虽然我们对语言恢复的理解已经取得了很大的进展，但还有更多的工作要做。未来的研究将需要检查中风后失语症的语言重组是否与大脑中残留和新区域的更紧密，更连贯和有效的网络相对应。回答这些问题将有助于预测哪些患者可能康复，并可能从未来的康复中受益。
This review focuses on three main topics related to the nature of poststroke language recovery and reorganization. The first topic pertains to the nature of anatomical and physiological substrates in the infarcted hemisphere in poststroke aphasia, including the nature of the hemodynamic response in patients with poststroke aphasia, the nature of the peri-infarct tissue, and the neuronal plasticity potential in the infarcted hemisphere. The second section of the paper reviews the current neuroimaging evidence for language recovery in the acute, subacute, and chronic stages of recovery. The third and final section examines changes in connectivity as a function of recovery in poststroke aphasia, specifically in terms of changes in white matter connectivity, changes in functional effective connectivity, and changes in resting state connectivity after stroke. While much progress has been made in our understanding of language recovery, more work needs to be done. Future studies will need to examine whether reorganization of language in poststroke aphasia corresponds to a tighter, more coherent, and efficient network of residual and new regions in the brain. Answering these questions will go a long way towards being able to predict which patients are likely to recover and may benefit from future rehabilitation.