SUPERSONIC SHEAR WAVE IMAGING OF THE SPLEEN FOR STAGING OF LIVER FIBROSIS IN RATS
SUPERSONIC SHEAR WAVE IMAGING OF THE SPLEEN FOR STAGING OF LIVER FIBROSIS IN RATS
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DOI：
10.1016/j.ultrasmedbio.2017.04.013
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发表时间：
2017-10-01
影响因子：
2.9
通讯作者：
Qian, Lin-Xue
中科院分区：
文献类型：
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作者：
Hu, Xiang-Dong;Geng, Hui-Ying;Qian, Lin-Xue
本研究的目的是探讨肝纤维化中脾僵硬的原因，并评价脾僵硬在肝纤维化分期中的价值。用四氯化碳(CCl4)诱导大鼠(n=40)低频。超声横波成像和超声造影测定肝脏硬度(LS)、SS和脾血流动力学。SS、LS和自由门脉压力与肝纤维化分期呈中度相关(r=0.744~0.835，p<；0.001)。脾超声造影的时间-强度曲线表现为峰值强度和斜率降低，峰值时间延长。病理组织学观察脾静脉窦扩张、充血。SS的受试者工作特征曲线下面积大于LS的受试者工作特征曲线下面积，以区分LF0-2和LF3-4(Z=2.293，P=0.02)。SS是评估CCl4模型中LF的可靠诊断指标，尤其是对严重的纤维化。门脉压力升高是SS升高的原因。(电子邮件：Qianlinxue2002@163.com)(C)2017由爱思唯尔公司代表世界超声医学与生物学联合会出版。
The goal of the work described here was to explore the cause of spleen stiffness (SS) in hepatic fibrogenesis and evaluate the value of SS in liver fibrosis (LF) staging. LF was induced with carbon tetrachloride (CCl4) in rats (n = 40). Supersonic shear wave imaging and contrast-enhanced ultrasound were performed to determine liver stiffness (LS), SS and splenic hemodynamics. SS, LS and free portal pressure exhibited moderate correlations with fibrosis stage (r = 0.744-0.835, p < 0.001). Time-intensity curves of contrast-enhanced ultrasound for the spleen were presented as decreasing peak intensity and slope of decrease, and increasing time to peak. Splenic sinus dilation and congestion were observed on histopathologic analysis. The area under the receiver operating characteristic curve of SS was higher than that of LS for differentiating LF stages 0-2 from stages 3-4 (Z = 2.293, p = 0.02). SS is a reliable diagnostic marker for the assessment of LF in the CCl4 model, especially for severe fibrosis. Elevated portal pressure is the cause of increasing SS. (E-mail: qianlinxue2002@163.com) (C) 2017 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.