The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors.
The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors.
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DOI：
10.1016/j.brainres.2009.08.062
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发表时间：
2010-02-16
期刊：
影响因子：
2.9
通讯作者：
Chavkin C
中科院分区：
文献类型：
--
作者：
Bruchas MR;Land BB;Chavkin C
压力是一种复杂的经历，既有令人厌恶的，也有激励人的。慢性压力会增加抑郁症的风险，众所周知会增加吸毒行为的复发，并会对健康产生不利影响。一些大脑系统已被证明是至关重要的，在调解与压力相关的负面影响，最近的证据直接联系的行动，内源性阿片类神经肽强啡肽在调节情绪和增加滥用药物的奖励效果。这些结果表明，强啡肽/κ阿片受体（KOR）系统的激活可能在应激的促成瘾作用中发挥重要作用。本文综述了强啡肽和促肾上腺皮质激素释放因子（CRF）在烦躁不安的诱导、药物寻求的增强和应激诱发的复跳中的关系。我们还提供了一个负责CRF和强啡肽/KOR依赖行为的信号转导事件的概述。了解最近的工作联系激活CRF和强啡肽/KOR系统及其在大脑应激系统和成瘾行为模型中的特定作用，为调节情感状态的神经肽系统提供了新的见解。
Stress is a complex experience that carries both aversive and motivating properties. Chronic stress causes an increase in the risk of depression, is well known to increase relapse of drug seeking behavior, and can adversely impact health. Several brain systems have been demonstrated to be critical in mediating the negative affect associated with stress, and recent evidence directly links the actions of the endogenous opioid neuropeptide dynorphin in modulating mood and increasing the rewarding effects of abused drugs. These results suggest that activation of the dynorphin/kappa opioid receptor (KOR) system is likely to play a major role in the pro-addictive effects of stress. This review explores the relationship between dynorphin and corticotropin releasing factor (CRF) in the induction of dysphoria, the potentiation of drug seeking, and stress-induced reinstatement. We also provide an overview of the signal transduction events responsible for CRF and dynorphin/KOR-dependent behaviors. Understanding the recent work linking activation of CRF and dynorphin/KOR systems and their specific roles in brain stress systems and behavioral models of addiction provides novel insight to neuropeptide systems that regulate affective state.
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