The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis
The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis
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DOI：
10.1093/hmg/6.12.2021
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发表时间：
1997-11-01
影响因子：
3.5
通讯作者：
Tycko, B
中科院分区：
文献类型：
--
作者：
Qian, N;Frank, D;Tycko, B
我们在人类染色体11p15.5的一个区域中寻找新的印迹基因，该区域包含几个已知的印迹基因。在这里，我们描述的克隆和表征的IPL（胎盘和肝脏中的印记）基因，其在许多人和小鼠组织中显示组织特异性表达和功能印记，其中母体等位基因活跃而父本等位基因相对不活跃。人IPL在胎盘中高度表达，并且在胎儿和成人肝脏和肺中显示低但可检测的表达，小鼠IPL定位于与人11p15.5同线的7号染色体区域，该基因在胎盘中表达，并且在胚外膜中以较高水平表达小鼠和人IPL显示出与TDAG 51的序列相似性，该基因被证明是T淋巴细胞系中Fas表达和细胞凋亡易感性所必需的。小鼠和人类IPL基因与其他几种印迹基因一样，都是小的，并且含有小的内含子。这些数据扩充了已知印迹基因的库，将有助于检验基因组印迹的机制以及印迹基因在生长调控中的作用。
We searched for novel imprinted genes in a region of human chromosome 11p15.5, which contains several known imprinted genes. Here we describe the cloning and characterization of the IPL (Imprinted in Placenta and Liver) gene, which shows tissue-specific expression and functional imprinting, with the maternal allele active and the paternal allele relatively inactive, in many human and mouse tissues, Human IPL is highly expressed in placenta and shows low but detectable expression in fetal and adult liver and lung, Mouse IPL maps to the region of chromosome 7 which is syntenic with human 11p15.5 and this gene is expressed in placenta and at higher levels in extraembryonic membranes (yolk sac), fetal liver and adult kidney, Mouse and human IPL show sequence similarity to TDAG51, a gene which was shown to be essential for Fas expression and susceptibility to apoptosis in a T lymphocyte cell line. Like several other imprinted genes, mouse and human IPL genes are small and contain small introns, These data expand the repertoire of known imprinted genes and will be helpful in testing the mechanism of genomic imprinting and the role of imprinted genes in growth regulation.