MUC2 and MUC6 apomucins expression in human gastric neoplasm: an immunohistochemical analysis
MUC2 and MUC6 apomucins expression in human gastric neoplasm: an immunohistochemical analysis
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DOI：
10.1007/s12032-010-9699-5
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发表时间：
2011-12-01
期刊：
影响因子：
3.4
通讯作者：
Lotfy, Mahmoud
中科院分区：
文献类型：
--
作者：
Khattab, Abdul-Zaher M.;Nasif, Wesam A.;Lotfy, Mahmoud
载脂粘蛋白在细胞-细胞和细胞-细胞外基质相互作用、细胞信号传导和癌细胞的生物学特性中发挥重要的生物学作用。它们在肿瘤向腺癌进展的不同步骤中的特定表达模式表明它们在肿瘤发生中起重要作用。分泌型粘蛋白家族，即保护上皮的粘弹性粘液凝胶的凝胶形成组分，包括粘蛋白MUC 2和MUC 6。它们的主要功能是通过寡聚化结构域形成三维网络来促进粘液形成，以保护下层上皮细胞免受各种损伤。本研究探讨胃癌组织中MUC 2和MUC 6的表达。应用特异性单克隆抗体免疫组化法检测胃癌活检组织中MUC 2和MUC 6的表达。结果表明，在我们的胃癌病例中，MUC 2的表达率为78.6%。从高分化到中分化再到低分化胃腺癌，MUC 2表达增加。另一方面，在32%的病例中检测到MUC 6。胃癌组织中MUC 2的表达增加，同时伴有MUC 6的表达改变。因此，可以得出结论，胃癌中MUC 2和MUC 6等分泌粘蛋白的表达模式发生了明显改变。
Apomucins play important biological roles in cell-cell and cell-extracellular matrix interactions, in cell signaling, and in biological properties of cancer cells. Their specific pattern of expression during the different steps of tumor progression toward adenocarcinoma suggests that they play significant roles in tumorigenesis. The family of secreted mucins, gel-forming components of viscoelastic mucus gels protecting the epithelia, includes mucins MUC2 and MUC6. Their principle function is to contribute in mucus formation by forming a tridimensional network via oligomerization domains to protect underlying epithelia against diverse injuries. The current study was investigated the expression of MUC2 and MUC6 in patients with gastric carcinoma. MUC2 and MUC6 expressions were detected immunohistochemically in gastric cancer biopsies using specific monoclonal antibodies. The results showed that in our gastric carcinoma cases, MUC2 expression was detected in 78.6% of cases. MUC2 expression is increased from well differentiated to moderately differentiated to poorly differentiated gastric adenocarcinoma. On the other hand, MUC6 was detected in 32% of cases. The expression of MUC2 is increasing, which is accompanied by an altered expression of MUC6 in gastric cancer. Therefore, it is concluded that the expression pattern of secreted mucins including MUC2 and MUC6 is altered apparently in gastric carcinoma.