Severe disease on endoscopy and steroid use increase the risk for bowel perforation during colonoscopy in inflammatory bowel disease patients
Severe disease on endoscopy and steroid use increase the risk for bowel perforation during colonoscopy in inflammatory bowel disease patients
复制标题
DOI：
10.1016/j.crohns.2011.10.005
复制
发表时间：
2012-05-01
影响因子：
8
通讯作者：
Shen, Bo
中科院分区：
文献类型：
--
作者：
Navaneethan, Udayakumar;Kochhar, Gursimran;Shen, Bo
背景和目的：结肠镜穿孔是一种罕见的并发症。我们试图确定炎症性肠病 (IBD) 患者的危险因素。 材料和方法：研究组由 19 名 2002 年 1 月至 2010 年 10 月期间因诊断性或治疗性结肠镜检查继发穿孔的 IBD 患者组成。对照组由 76 名接受结肠镜检查且无穿孔的 IBD 患者组成，根据适应症与研究组按 4:1 的比例进行匹配。通过单变量和多变量分析对人口统计学和临床变量以及穿孔结果进行分析。结果：研究期间总共对 IBD 患者进行了 5295 例结肠镜检查，其中 19 例患者发生穿孔。 IBD 患者穿孔的发生率为 0.3%。 19 名患者中，12 名患有克罗恩病 (CD)，7 名患有溃疡性结肠炎 (UC)。穿孔组患者更有可能接受类固醇治疗（68.4% vs. 21.1%，p
Background and aim: Colonoscopic perforation is a rare complication. We sought to determine its risk factors in patients with inflammatory bowel disease (IBD).Materials and methods: The study group consisted of 19 IBD patients who had perforation secondary to diagnostic or therapeutic colonoscopy from January 2002 to October 2010. The control group consists of 76 IBD patients undergoing colonoscopy and no perforations that were matched based on indication in a 4:1 ratio to the study group. Demographic and clinical variables as well as perforation outcomes were analyzed by univariate and multivariate analyses.Results: There were a total of 5295 colonoscopies done during the study period in IBD patients of which 19 patients had perforation. The prevalence of perforation in IBD patients was 0.3%. Of the 19 patients, 12 had Crohn's disease (CD) and 7 had ulcerative colitis (UC). Patients in the perforation group were more likely treated with steroids (68.4% vs. 21.1%, p