Nanoscale Structures of Poly(oligo ethylene glycol methyl ether methacrylate) Hydrogels Revealed by Small-Angle Neutron Scattering
Nanoscale Structures of Poly(oligo ethylene glycol methyl ether methacrylate) Hydrogels Revealed by Small-Angle Neutron Scattering
复制标题
DOI：
10.1021/acs.macromol.1c02259
复制
发表时间：
2022-02
期刊：
影响因子：
5.5
通讯作者：
Takuma Kureha;Masashi Ohira;Yuki Takahashi;Xiang Li;E. Gilbert;M. Shibayama
中科院分区：
文献类型：
--
作者：
Takuma Kureha;Masashi Ohira;Yuki Takahashi;Xiang Li;E. Gilbert;M. Shibayama
利用小角中子散射（SANS）研究了温度响应性和生物相容性凝胶的纳米结构。使用具有不同乙二醇侧链长度的两种类型的单体：二甘醇甲基丙烯酸酯（MeO2MA）（短侧链）和低聚乙二醇甲基醚甲基丙烯酸酯（OEGMA）（长侧链）共聚凝胶。温度响应行为归因于纳米结构，并取决于共聚比例。溶胀的富含OEGMA的凝胶的SANS曲线表现出特征峰，表明与亲水基质中的疏水主链结构域的强相关性。OEGMA的长亲水侧链充当域之间的缓冲材料。另一方面，域随机分布在MeO2MA丰富的凝胶。随着温度的升高，由于脱水聚合物之间的疏水相互作用，微区在凝胶中生长。结果，峰，即，域周期性，消失在SANS轮廓。本研究的结果应导致一种合成策略，以控制这种水凝胶的物理性质和结构，用于高级应用，例如，生物膜，涂层和载体。
The nanostructures of temperature-responsive and biocompatible gels were investigated by small-angle neutron scattering (SANS). The gels were copolymerized using two types of monomers with different ethylene glycol side chain lengths: diethylene glycol methacrylate (MeO2MA) (short side chain) and oligo-ethylene glycol methyl ether methacrylate (OEGMA) (long side chain). The temperature-responsive behavior was ascribed to the nanoscale structures and depended on the copolymerization ratio. The SANS profiles of swollen OEGMA-rich gels exhibited a characteristic peak, indicating a strong correlation with the hydrophobic main chain domains in the hydrophilic matrix. The long hydrophilic side chains of OEGMA acted as a cushioning material between the domains. On the other hand, the domains were randomly distributed in the MeO2MA-rich gels. As the temperature increased, the domains grew in the gels due to hydrophobic interactions between the dehydrated polymers. As a result, the peaks, that is, the domain periodicity, disappeared in the SANS profiles. The results of this study should lead to a synthesis strategy to control the physical properties and structures of such hydrogels for advanced applications, for example, biofilms, coatings, and carriers.