The long-term predictive value of bone mineral density measurements for fracture risk is independent of the site of measurement and the age at diagnosis:: results from the Prospective Epidemiological Risk Factors study
The long-term predictive value of bone mineral density measurements for fracture risk is independent of the site of measurement and the age at diagnosis:: results from the Prospective Epidemiological Risk Factors study
复制标题
DOI：
10.1007/s00198-005-0009-6
复制
发表时间：
2006-03-01
影响因子：
4
通讯作者：
Christiansen, C
中科院分区：
文献类型：
--
作者：
Bagger, YZ;Tankó, LB;Christiansen, C
尽管骨量测量的效用已成为广泛研究的主题，但将同一队列中不同骨骼部位的骨量测量预测值与大量经临床验证的终点进行比较的研究数量有限。此外，关于诊断时的年龄如何影响低骨矿物质密度（BMD）造成的未来骨折风险的信息很少。我们对5,564名丹麦绝经后妇女进行了平均7.3年的随访。在基线时评估前臂的骨矿物质含量（BMC）以及脊柱和髋关节的BMD。椎体骨折通过胸椎和腰椎侧位X线片的数字化图像进行评估，而非椎体骨折则是自我报告的。在随访中，17.6%的女性发现了偶然的椎骨骨折，14.2%的女性报告了新的非椎骨骨折。每1,000人-年发生骨质疏松性骨折的绝对风险随三个骨骼部位骨量的减少而显著增加（P < 0.001）。骨质疏松BMD（T评分
Although the utility of bone mass measurements has been the subjects of extensive investigations, the number of studies comparing the predictive value of bone mass measurement at different skeletal sites in the same cohort with a large number of clinically verified endpoints is limited. Furthermore, scant information is available on how age at the time of diagnosis influence the risk of future fractures posed by low bone mineral density (BMD). We have followed 5,564 Danish postmenopausal women for a mean period of 7.3 years. Bone mineral content (BMC) at the forearm and BMD at the spine and hip were assessed at baseline. Vertebral fractures were assessed on digitalized images of lateral X-rays of the thoracic and lumbar spine, whereas non-vertebral fractures were self-reported. At follow-up, 17.6% of the women revealed an incidental vertebral fracture and 14.2% reported a new non-vertebral fracture. The absolute risk per 1,000 person-years of osteoporotic fracture increased significantly with decreasing bone mass at all three skeletal sites (P < 0.001). Osteoporotic BMD (T-score