Endothelial progenitor cells: Regulation and contribution to adult neovascularization
Endothelial progenitor cells: Regulation and contribution to adult neovascularization
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DOI：
10.1007/s00059-002-2427-y
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发表时间：
2002-11-01
期刊：
影响因子：
1.7
通讯作者：
Dimmeler, S
中科院分区：
文献类型：
--
作者：
Walter, DH;Dimmeler, S
背景：最近的研究表明，循环祖细胞有助于组织缺血后成人新血管的形成。这些祖细胞的输注被用作增加血管形成的治疗方法。在一些动物模型中，祖细胞改善了外周或心肌缺血后的血管形成和毛细血管密度。此外，祖细胞移植增加心肌缺血后的心脏功能。这些研究表明，一个潜在的使用祖细胞改善缺血性心脏病患者的治疗性血管生成。现状：本文将总结这些发现在实验模型中获得。此外，通过药理学调节增加循环祖细胞的功能和数量的新方法，（细胞因子，他汀类药物）或基因治疗（VEGF）将被强调。鉴定促进器官特异性骨募集的介质和细胞机制-骨髓来源的循环祖细胞以及祖细胞植入的调节将导致新的策略，以改善新血管形成，缺血性心脏病患者的心脏再生。
Background: Recent studies suggest that circulating progenitor cells contribute to the formation of new blood vessels in adults after tissue ischemia. The infusion of these progenitor cells was used as a therapeutic approach to increase vascularization. In several animal models, progenitor cells improved vascularization and capillary density after peripheral or myocardial ischemia. Moreover, transplantation of progenitor cells increased cardiac function after myocardial ischemia. These studies suggest a potential use of progenitor cells for improvement of therapeutic vasculogenesis in patients with ischemic heart disease.Present State: The present article will summarize these findings gained in experimental models. Moreover, novel approaches to increase the function and the number of circulating progenitor cells by pharmacological modulation (cytokines, statins) or gene therapy (VEGF) will be highlighted.Conclusion: Identification of mediators and cellular mechanisms that promote organ-specific recruitment of bone-marrow derived circulating progenitor cells as well as modulation of progenitor cell engraftment will lead to new strategies in order to improve neovascularization and cardiac regeneration in patients with ischemic heart disease.