Effects of hawthorn on cardiac remodeling and left ventricular dysfunction after 1 month of pressure overload-induced cardiac hypertrophy in rats
Effects of hawthorn on cardiac remodeling and left ventricular dysfunction after 1 month of pressure overload-induced cardiac hypertrophy in rats
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DOI：
10.1007/s10557-008-6082-2
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发表时间：
2008-02-01
影响因子：
3.4
通讯作者：
Boluyt, Marvin O.
中科院分区：
文献类型：
--
作者：
Hwang, Hyun Seok;Bleske, Barry E.;Boluyt, Marvin O.
山楂（山楂）是一种用于治疗心力衰竭患者的天然产品。然而，山楂对心脏重塑的影响尚不清楚。目的是观察山楂处理对压力超负荷引起的心肌肥厚1个月后左心室（LV）重构和功能的影响。材料与方法Sprague-Dawley大鼠（雄性，300 g）假手术（SH）或主动脉收缩（AC） 4周后，给予山楂(山楂提取物- WS1442；1.3、13、130 mg kg(-1) day(-1)；AC-L, AC-M, AC-H)或载体（SH-V, AC-V）术后3周。采用超声心动图法测定各组大鼠的心脏收缩和舒张功能。结果山楂治疗组和载药组大鼠的左室/体重比均提高34%。山楂明显降低交流后左室容积（VOL）[收缩期VOL，平均值+/- SEM， mm(3): SH-V, 87 +/- 13；Ac-v, 93 +/- 12；ac - 1, 62 +/- 9；Ac-m, 68 +/- 12；AC-H;50 +/- 11，舒张VOL: SH-V， 433 +/- 45；Ac-v, 412 +/- 57；ac - 1, 313 +/- 25；Ac-m, 319 +/- 37；AC-H, 264 +/- 25 (p
Purpose Hawthorn (Crataegus) is a natural product used to treat patients with heart failure. The effects of hawthorn on cardiac remodeling, however, are not known. The purpose was to determine the effects of hawthorn treatment on remodeling and function of the left ventricle (LV) after 1 month of pressure overload-induced cardiac hypertrophy.Materials and methods Sprague-Dawley rats (male, 300 g) were subjected to sham operation (SH) or aortic constriction (AC) for 4 weeks and treated with Hawthorn (Crataegus-Extract- WS1442;1.3, 13, 130 mg kg(-1) day(-1); AC-L, AC-M, AC-H) or vehicle (SH-V, AC-V) for 3 weeks after surgery. Systolic and diastolic function were measured using echocardiographic assessment at baseline and 4 weeks after AC.Results AC increased the LV/body weight ratio by 34% in vehicle and hawthorn treated rats. Hawthorn markedly reduced LV chamber volumes (VOL) after AC [systolic VOL, mean +/- SEM, mm(3): SH-V, 87 +/- 13; AC-V, 93 +/- 12; AC-L, 62 +/- 9; AC-M, 68 +/- 12; AC-H; 50 +/- 11 and diastolic VOL: SH-V, 433 +/- 45; AC-V, 412 +/- 57; AC-L, 313 +/- 25; AC-M, 319 +/- 37; AC-H, 264 +/- 25 (p