Control of Streptococcus pneumoniae serotype 5 epidemic of severe pneumonia among young army recruits by mass antibiotic treatment and vaccination
Control of Streptococcus pneumoniae serotype 5 epidemic of severe pneumonia among young army recruits by mass antibiotic treatment and vaccination
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DOI：
10.1016/j.vaccine.2010.06.031
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发表时间：
2010-08-02
期刊：
影响因子：
5.5
通讯作者：
Dagan, Ron
中科院分区：
文献类型：
--
作者：
Balicer, Ran D.;Zarka, Salman;Dagan, Ron
在新入伍新兵中暴发重症肺炎期间，进行了流行病学调查，并对患病和健康接触者进行了反复鼻咽/口咽培养。在2005年12月的4周内，596名新兵中发生了15例肺炎和19例流感样疾病。肺炎发病率高达5.5%。从4例患者和30/124（24.1%）接触者的血液或痰培养中分离出单一肺炎球菌血清5型克隆。用23价多糖疫苗免疫并辅以2剂阿奇霉素大规模治疗迅速终止了疫情。运费下降到
During an outbreak of severe pneumonia among new army recruits, an epidemiological investigation combined with repeated nasopharyngeal/oropharyngeal cultures from sick and healthy contacts subjects was conducted. Fifteen pneumonia cases and 19 influenza-like illness cases occurred among 596 recruits over a 4-week period in December 2005. Pneumonia attack rates reached up to 5.5%. A single pneumococcus serotype 5 clone was isolated from blood or sputum cultures in 4 patients and 30/124 (24.1%) contacts. Immunization with 23-valent polysaccharide vaccine supplemented with a 2-dose azithromycin mass treatment rapidly terminated the outbreak. Carriage rates dropped to