P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study
P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study
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DOI：
10.1016/j.hrthm.2015.04.026
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发表时间：
2015-09-01
期刊：
影响因子：
5.5
通讯作者：
Holst, Anders G.
中科院分区：
文献类型：
--
作者：
Nielsen, Jonas B.;Kuehl, Jorgen T.;Holst, Anders G.
背景：关于p波持续时间与心房颤动（AF）风险之间关系的结果是相互矛盾的。目的：本研究的目的是获得p波持续时间与房颤风险之间关系的详细描述。方法：通过对大量初级保健人群的心电图进行计算机分析，我们评估了p波持续时间与房颤风险之间的关系。次要终点是心血管原因导致的死亡和假定的缺血性卒中。药物使用、合并症和结果的数据从行政登记处收集。结果共纳入285933人。在平均6.7年的随访期间，9550人发生房颤，9371人死于心血管疾病，8980人中风。与参照组（100-105 ms）相比，非常短的个体（= 130 ms; HR 2.06, 95% CI 1.89-2.23）发生AF的风险增加。关于心血管原因死亡，我们发现非常短的个体（= 130 ms; HR 1.30, 95% CI 1.21-1.40）与参照组（106-111 ms）相比风险增加。在p波持续时间和假定的缺血性中风风险之间发现了类似但较弱的关联。结论：在大量的初级保健人群中，我们发现短和长p波持续时间与房颤风险增加密切相关。
BACKGROUND Results on the association between P-wave duration and the risk of atrial fibrillation (AF) are conflicting.OBJECTIVE The purpose of this study was to obtain a detailed description of the relationship between P-wave duration and the risk of AF.METHODS Using computerized analysis of electrocardiograms from a large primary care population, we evaluated the association between P-wave duration and the risk of AF. Secondary end-points were death from cardiovascular causes and putative ischemic stroke. Data on drug use, comorbidity, and outcomes were collected from administrative registries.RESULTS A total of 285,933 individuals were included. During median follow-up period of 6.7 years, 9550 developed AF, 9371 died of a cardiovascular cause, and 8980 had a stroke. Compared with the reference group (100-105 ms), individuals with very short (= 130 ms; HR 2.06, 95% CI 1.89-2.23) had an increased risk of incident AF. With respect to death from cardiovascular causes, we found an increased risk for very short (= 130 ms; HR 1.30, 95% CI 1.21-1.40) compared with the reference group (106-111 ms). Similar but weaker associations were found between P-wave duration and the risk of putative ischemic stroke.CONCLUSION In a large primary care population we found both short and Long P-wave duration to be robustly associated with an increased risk of AF.