Long-term outcomes in systemic lupus erythematosus: trends over time and major contributors.
Long-term outcomes in systemic lupus erythematosus: trends over time and major contributors.
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DOI：
10.1093/rheumatology/keaa382
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发表时间：
2020-12-05
期刊：
影响因子：
--
通讯作者：
Tektonidou MG
中科院分区：
文献类型：
--
作者：
Arnaud L;Tektonidou MG
SLE是一种慢性自身免疫性风湿性疾病，在临床表现、治疗反应和预后方面具有高度异质性。在过去的几十年中，SLE的长期结局已得到显著改善，但发病率和死亡率仍在增加，尤其是在年轻人中。未满足的需求包括残留疾病活动和频繁发作、糖皮质激素治疗依赖和毒性、合并症负担、与健康有关的生活质量下降、健康差异和损害。SLE长期结局的主要决定因素包括年龄、性别、人种/种族、遗传特征、环境因素（包括吸烟）、疾病活动、主要器官受累（如狼疮性肾炎和CNS受累）、合并症（包括心血管疾病和严重感染）、与APS共存、治疗依从性、社会经济因素和获得护理。在这篇综述中，我们讨论了多年来SLE长期结局的趋势和主要因素，如遗传、疾病相关、治疗、合并症、社会经济和其他因素。
SLE is a chronic autoimmune rheumatic disorder of high heterogeneity in clinical presentation, treatment response and prognosis. Long-term outcomes in SLE have been dramatically improved over the past decades, however, increased morbidity and mortality, especially among young individuals, still exists. Unmet needs include residual disease activity and frequent flares, glucocorticoid treatment dependency and toxicity, comorbidity burden, reduced health-related quality of life, health disparities and damage. The main determinants of long-term outcomes in SLE are age, sex, race/ethnicity, genetic profile, environmental factors including smoking, disease activity, major organ involvement such as lupus nephritis and CNS involvement, comorbidities including cardiovascular disease and serious infections, coexistence with APS, treatment adherence, socio-economic factors and access to care. In this review we discuss trends in long-term outcomes in SLE over the years and major contributors such as genetic, disease-related, treatment, comorbidity, socio-economic and other factors.
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影响因子：
27.4
作者：
Bertsias GK;Tektonidou M;Amoura Z;Aringer M;Bajema I;Berden JH;Boletis J;Cervera R;Dörner T;Doria A;Ferrario F;Floege J;Houssiau FA;Ioannidis JP;Isenberg DA;Kallenberg CG;Lightstone L;Marks SD;Martini A;Moroni G;Neumann I;Praga M;Schneider M;Starra A;Tesar V;Vasconcelos C;van Vollenhoven RF;Zakharova H;Haubitz M;Gordon C;Jayne D;Boumpas DT;European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
通讯作者：
European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
影响因子：
5.1
作者：
Deng Y;Tsao BP
通讯作者：
Tsao BP
DOI：
10.1016/j.berh.2013.07.001
发表时间：
2013-06-01
影响因子：
5.2
作者：
Costedoat-Chalumeau, Nathalie;Pouchot, Jacques;Piette, Jean-Charles
通讯作者：
Piette, Jean-Charles
影响因子：
13.8
作者：
Chasset, Francois;Frances, Camille;Arnaud, Laurent
通讯作者：
Arnaud, Laurent
影响因子：
3.4
作者：
Falasinnu, Titilola;Chaichian, Yashaar;Simard, Julia F.
通讯作者：
Simard, Julia F.