Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure
Optimization of Magneto-thermally Controlled Release Kinetics by Tuning of Magnetoliposome Composition and Structure
复制标题
通过调整磁脂质体组成和结构优化磁热控释动力学
作者：
B. Shirmardi Shaghasemi;M. Virk;E. Reimhult
隐形（聚乙二醇化）脂质体在药物制剂和递送中发挥了核心作用，结合了高效转运和低非特异性相互作用。在特定地点和时间控制快速释放仍然是一项挑战，取决于环境因素。我们展示了一种高效和可扩展的方法来生产任何脂质组合物的脂质体，该脂质体在膜内部含有均匀分散的单分散超顺磁性氧化铁纳米颗粒。我们研究了脂质组成，颗粒浓度和磁场驱动对胶体稳定性，磁热驱动释放和被动释放速率的影响。我们表明，通过使用交变磁场驱动释放的包封的亲水性化合物的速率和量可以精确地控制从隐形脂质体具有高的膜熔融温度。在体温下极低的被动释放和温度敏感性使其成为一种有前途的封装和外部触发按需释放系统。所介绍的特征可以用作现有隐形脂质体药物递送技术的附加物。
Stealth (PEGylated) liposomes have taken a central role in drug formulation and delivery combining efficient transport with low nonspecific interactions. Controlling rapid release at a certain location and time remains a challenge dependent on environmental factors. We demonstrate a highly efficient and scalable way to produce liposomes of any lipid composition containing homogeneously dispersed monodisperse superparamagnetic iron oxide nanoparticles in the membrane interior. We investigate the effect of lipid composition, particle concentration and magnetic field actuation on colloidal stability, magneto-thermally actuated release and passive release rates. We show that the rate and amount of encapsulated hydrophilic compound released by actuation using alternating magnetic fields can be precisely controlled from stealth liposomes with high membrane melting temperature. Extraordinarily low passive release and temperature sensitivity at body temperature makes this a promising encapsulation and external-trigger-on-demand release system. The introduced feature can be used as an add-on to existing stealth liposome drug delivery technology.
影响因子：
10.8
作者：
Auguste, Debra T.;Furman, Kay;Langer, Robert
通讯作者：
Langer, Robert
影响因子：
15
作者：
Turkyilmaz S;Chen WH;Mitomo H;Regen SL
通讯作者：
Regen SL