Meroterpenoids from the fruits of Psoralea corylifolia
Meroterpenoids from the fruits of Psoralea corylifolia
复制标题
补骨脂果实中的小萜类化合物
DOI：
10.1016/j.tet.2020.131343
复制
发表时间：
2020-07-31
期刊：
影响因子：
2.1
通讯作者：
Yang, Xiu-Wei
中科院分区：
文献类型：
--
作者：
Xu, Qing-Xia;Xu, Wei;Yang, Xiu-Wei
本文报道了14个新的高萜类化合物（corypsoriols A-N（1-14））和8个已知化合物（15-22）。通过NOESY光谱、ECD计算和单晶X-射线衍射确定了化合物的绝对构型。Corypsoriols A和B是一种新的具有6/5/6三环结构的骨架化合物，并提出了它们可能的生物合成途径。未环化的部分萜类化合物的细胞毒性比环化的部分萜类化合物的细胞毒性强，并且bakuchiol（15）对NCI-N87、HepG 2、HCT-116、Hela和B16-F10细胞系的半最大抑制浓度值在5-20 μ M范围内。(C)2020爱思唯尔有限公司保留所有权利。
Fourteen new meroterpenoid compounds, corypsoriols A-N (1-14), and eight known ones (15-22), were isolated from the fruits of Psoralea corylifolia. The absolute configurations of these new compounds were confirmed by NOESY spectrum, ECD calculation, and single crystal X-ray diffraction. Corypsoriols A and B were a novel skeleton which possessed a 6/5/6 tricyclic system, and their plausible biosynthetic pathway was proposed. The cytotoxicity of uncyclized meroterpenoids were stronger than those of cyclized ones, and the half maximal inhibitory concentration values of bakuchiol (15) against NCI-N87, HepG2, HCT-116, Hela and B16-F10 cell lines were in the range of 5-20 mu M. (C) 2020 Elsevier Ltd. All rights reserved.