The impact of the aortic pulse wave velocity on the cardiovascular outcomes of hemodialysis patients.
The impact of the aortic pulse wave velocity on the cardiovascular outcomes of hemodialysis patients.
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DOI：
10.3346/jkms.2009.24.s1.s121
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发表时间：
2009-01
影响因子：
4.5
通讯作者：
Choi, Eui-Jin
中科院分区：
文献类型：
--
作者：
Shin, Seok Joon;Kim, Yong Kyun;Chung, Sungjin;Chung, Hyun Wha;Ihm, Sang Hyun;Park, Cheol Whee;Kim, Young Ok;Song, Ho Cheol;Kim, Yong Soo;Choi, Eui-Jin
本研究的目的是确定主动脉脉搏波速度（AoPWV）增加的危险因素，并评估AoPWV对血液透析（HD）患者心血管（CV）结局的影响。对72例HD患者进行AoPWV、超声心动图和生化指标的检测。根据AoPWV值将患者分为三分位后，我们定义了低，中，高AoPWV组。高AoPWV组患者的年龄、高敏C反应蛋白水平、糖尿病患病率、他汀类药物使用率、左室肥厚、平均脉压、AoPWV和左室质量指数均显著高于低AoPWV组（p<0.05），血清白蛋白水平显著低于低AoPWV组（p<0.05）。多因素回归分析显示，年龄、平均PP与AoPWV独立相关（p<0.05）。在CV结局的多变量考克斯分析中，AoPWV和平均PP仍然是CV事件的显著独立预测因素。我们的数据表明，AoPWV增加是HD患者CV结局的独立预测因素。
The aims of our study were to identify the risk factors for an increased aortic pulse wave velocity (AoPWV) and to assess the impact of the AoPWV on the cerebro-cardiovascular (CV) outcomes of hemodialysis (HD) patients. Seventy two HD patients were included, and the AoPWV, the echocardiography and the biochemical parameters were measured. After dividing the patients into tertiles according to the AoPWV values, we defined the low, the middle and the high AoPWV groups. The patients in the high AoPWV group showed a significantly higher age and high-sensitivity C-reactive protein level, a greater prevalence of diabetes and statin use, left ventricular hypertrophy, average pulse pressure (PP), AoPWV and left ventricular mass index and a lower serum albumin level than those in the low AoPWV group (p<0.05). On multivariate regression analysis of the AoPWV, age and the average PP were independently related to the AoPWV (p<0.05). On the multivariate Cox analysis for CV outcomes, the AoPWV and the average PP remained significant independent predictors of CV events. Our data suggest that an increased AoPWV is an independent predictor for the CV outcomes of HD patients.