EEG frequency profiles of idiopathic generalised epilepsy syndromes
EEG frequency profiles of idiopathic generalised epilepsy syndromes
复制标题
DOI：
10.1016/s0920-1211(00)00167-4
复制
发表时间：
2000-12-01
影响因子：
2.2
通讯作者：
Barta, Z
中科院分区：
文献类型：
--
作者：
Clemens, B;Szigeti, G;Barta, Z
本研究的目的是调查EEG频率分布（频谱功率数据的地形分布）在明确定义的特发性全身性癫痫（IGE）综合征：青少年失神癫痫（JAE），青少年肌阵挛性癫痫（JME），癫痫大发作觉醒（EGMA），并在统一的“普通IGE”（CIGE）组的这些患者。方法：通过快速傅立叶变换（FFT）计算清醒脑电活动的绝对和相对（百分比）功率值。将每个患者组与年龄匹配的健康对照组进行比较。结果如下：与对照组相比，在所有IGE组中存在弥漫性（绝对和相对）δ-θ-α功率过剩和相对β功率不足的一般趋势。统计学显著性（P小于或等于0.05）双侧绝对功率差异为：额顶叶δ和弥漫性θ（JAE）、额叶δ（JME）和额叶α（EGMA）。具有统计学显著性（P小于或等于0.05）的相对功率差异为：额叶δ、弥漫性θ、额叶-中央-顶叶β（JAE）、额叶δ和β（JME）以及额叶-中央α（EGMA）。CIGE组显示相同类型的功率改变，但差异在统计学上比其他患者组更显著。结论：绝对功率结果被解释为在0.5-12.0 Hz频率范围内增强的神经元同步性以及在更快（12.5-32.0 Hz）频率下降低同步性的趋势。相对功率的相应变化被解释为反映了皮质区域的功能障碍。作者假设，这些IGE频率曲线反映了广泛的皮质功能障碍，基本上是所有研究的IGE综合征的共同点。(C)2000 Elsevier Science B. V.保留所有权利。
The objective of this study was to investigate EEG frequency profiles (topographic distribution of spectral power data) in well-defined idiopathic generalised epilepsy (IGE) syndromes: juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), epilepsy with grand mal seizures on awakening (EGMA), and in the unified 'common IGE' (CIGE) group of these patients. Methods: Absolute and relative (percent) power values were computed from waking EEG activity by Fast Fourier Transform (FFT). Each patient group was compared to an age-matched group of healthy control persons. Results: There was a general tendency for diffuse (absolute and relative) delta-theta-alpha power excess and relative beta power deficit in all IGE groups as compared to controls. Statistically significant (P less than or equal to 0.05) bilateral absolute power differences were: fronto-parietal delta and diffuse theta (in JAE), frontal delta (in JME) and frontal alpha (in EGMA). Statistically significant (P less than or equal to 0.05) relative power differences were: frontal delta, diffuse theta, fronto-centro-parietal beta (in JAE), frontal delta and beta (in JME) and fronto-central alpha (in EGMA). The CIGE group showed power alterations of the same type but differences were statistically more significant than in the other patient groups. Conclusion: Absolute power findings were interpreted as enhanced neuronal synchrony in the 0.5-12.0 Hz frequency range together with the tendency of decreasing synchrony in faster (12.5-32.0 Hz) frequencies. Corresponding shifts in relative power were interpreted as reflecting dysfunction of cortical regions. The authors hypothesise that these IGE frequency profiles reflect widespread cortical dysfunction essentially common to all the investigated IGE syndromes. (C) 2000 Elsevier Science B.V. All rights reserved.