DIFFERENTIAL-EFFECTS OF ETHANOL ON THE FIRING RATES OF GOLGI-LIKE NEURONS AND PURKINJE NEURONS IN CEREBELLAR SLICES IN-VITRO
DIFFERENTIAL-EFFECTS OF ETHANOL ON THE FIRING RATES OF GOLGI-LIKE NEURONS AND PURKINJE NEURONS IN CEREBELLAR SLICES IN-VITRO
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DOI：
10.1016/0304-3940(93)90844-b
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发表时间：
1993-12-24
影响因子：
2.5
通讯作者：
PALMER, MR
中科院分区：
文献类型：
--
作者：
FREUND, RK;WANG, Y;PALMER, MR
以往的研究表明，乙醇（EtOH）抑制浦肯野神经元的放电率在体外和体内。然而，很少有人知道小脑中间神经元的反应乙醇。在这份报告中，我们描述的影响，局部应用乙醇的一种类型的小脑中间神经元，暂时确定为高尔基体神经元，并在体外脑切片中的浦肯野细胞的发射。乙醇可使高尔基体神经元兴奋，而抑制浦肯野神经元的放电频率。据我们所知，这是第一次报告的反应，小脑高尔基神经元的局部应用乙醇。
Previous studies have demonstrated that ethanol (EtOH) inhibits the firing rate of Purkinje neurons both in vitro and in vivo. However, little is known about the response of cerebellar interneurons to EtOH. In this report, we describe the effects of locally applied EtOH on the firing of one type of cerebellar interneuron, tentatively identified as Golgi neurons, and on Purkinje cells in brain slices in vitro. The Golgi neurons were excited by EtOH, whereas EtOH depressed the firing rate of Purkinje neurons. To the best of our knowledge, this is the first report of responses of cerebellar Golgi neurons to local applications of EtOH.